The allogeneic response and tumor immunity

被引：84
作者：
Fabre, JW [1 ]
机构：
[1] Guys Kings & St Thomas Sch Med, Inst Liver Studies, Dept Clin Sci, London, England
来源：
NATURE MEDICINE | 2001年 / 7卷 / 06期
基金：
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词：
D O I：
10.1038/89008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The strong allogeneic response to donor MHC molecules in transplantation and the weak response to tumor antigens represent two important and divergent but potentially interactive immune responses. A patient's response to allogeneic MHC molecules might promote an effective T-cell response to self MHC-restricted tumor peptides and the possibilities for this are discussed here. These allogeneic responses might successfully be harnessed to promote the immune eradication of metastatic cancer.
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页码：649 / 652
页数：4
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