Protective effects of rambutan (Nephelium lappaceum) peel phenolics on H2O2-induced oxidative damages in HepG2 cells and D-galactose induced aging mice

被引：124
作者：
Zhuang, Yongliang [1 ]
Ma, Qingyu [1 ]
Guo, Yan [1 ]
Sun, Liping [1 ]
机构：
[1] Kunming Univ Sci & Technol, Yunnan Inst Food Safety, 727 South Jingming Rd, Kunming 650500, Yunnan, Peoples R China
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2017年 / 108卷
基金：
中国国家自然科学基金;
关键词：
Rambutan peel phenolics; UPLC-MS/MS; Oxidative stress; HepG2; cells; D-galactose-induced aging mice; Histological analysis; ANTIOXIDANT ACTIVITIES; IN-VITRO; DIETARY POLYPHENOLS; STRESS; PURIFICATION; HYDROLYSATE; PERSIMMON; EXTRACTS; PLANTS; SEED;
D O I：
10.1016/j.fct.2017.01.022
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Rambutan peel phenolic (RPP) extracts were prepared via dynamic separation with macroporous resin. The total phenolic content and individual phenolics in RPP were determined. Results showed that the total phenolic content of RPP was 877.11 mg gallic acid equivalents (GAE)/g extract. The content of geranin (122.18 mg/g extract) was the highest among those of the 39 identified phenolic compounds. RPP protected against oxidative stress in H2O2-induced HepG2 cells in a dose-response manner. The inhibitory effects of RPP on cell apoptosis might be related to its inhibitory effects on the generation of intracellular reactive oxygen species and increased effects on superoxide dismutase activity. The in vivo anti-aging activity of RPP was evaluated using an aging mice model that was induced by D-galactose (D-gal). The results showed that RPP enhanced the antioxidative status of experimental mice. Moreover, histological analysis indicated that RPP effectively reduced D-gal-induced liver and kidney tissue damage in a dose-dependent manner. Therefore, RPP can be used as a natural antioxidant and anti-aging agent in the pharmaceutical and food industries. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：554 / 562
页数：9
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