The role of the invariant chain in mucosal immunity

被引:11
作者
Barrera, CA
Almanza, RJ
Ogra, PL
Reyes, VE
机构
[1] Univ Texas, Med Branch, Dept Pediat, Galveston, TX 77555 USA
[2] Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA
关键词
invariant chain; class II MHC; T cell activation; antigen presenting cells; mucosal immunity;
D O I
10.1159/000023994
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The invariant chain (Ii) due to its intimate association with major histocompatibility complex (MHC) alpha and beta chains is a determining element in the development of immune responses. Ii plays a major role in the assembly, the intracellular transport and peptide selection by class II MHC. A segment of Ii designated as CLIP (class II-associated Ii peptide) binds into the antigen binding site of class II MHC molecules until class II MHC reach intracellular compartments that contain peptides from internalized antigens. This association limits the self endogenous peptides that can bind to class II MHC molecules. The removal of CLIP from class II MHC catalyzes the binding of antigenic peptides and their subsequent cell surface expression. An isoform of Ii, known as chondroitin sulfate-modified Ii (IiCS), that is surface-expressed enhances T cell activation while acting as a coreceptor for CD44. The expression of class II MHC molecules by mucosal epithelial cells has generated interest in the role that these cells may have in mucosal immunity. Since in classical antigen-presenting cells (APC) the biology of class II MHC is regulated by Ii, it is necessary to bring into perspective the known functions of Ii in conventional APC to understand the role that Ii may play in mucosal epithelial cells as potential regulators of local immune responses.
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页码:85 / 93
页数:9
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