Synthesis of 4-pyrido-6-aryl-2-substituted amino pyrimidines as a new class of antimalarial agents

被引：37
作者：
Agarwal, A
Srivastava, K
Puri, SK
Chauhan, PMS [1 ]
机构：
[1] Cent Drug Res Inst, Div Med & Proc Chem, Lucknow 226001, Uttar Pradesh, India
[2] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 22期
关键词：
dihydrofolate reductase; antimalarial; pyrimidine;
D O I：
10.1016/j.bmc.2005.06.052
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of 2,4,6-trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds showed MIC in the range of 0.25-2 mu g/mL. These compounds are in vitro several fold more active than pyrimethamine.. (c) 2005 Published by Elsevier Ltd.
引用
收藏
页码：6226 / 6232
页数：7
相关论文
共 50 条
  • [41] New V-shaped push-pull systems based on 4,5-di(hetero)aryl substituted pyrimidines: their synthesis and application to the detection of nitroaromatic explosives
    Verbitskiy, Egor V.
    Baranova, Anna A.
    Lugovik, Kseniya I.
    Khokhlov, Konstantin O.
    Cheprakova, Ekaterina M.
    Rusinov, Gennady L.
    Chupakhin, Oleg N.
    Charushina, Valery N.
    [J]. ARKIVOC, 2016, : 360 - 373
  • [42] Highly efficient magnetically separable Zn-Ag@L-arginine Fe3O4 catalyst for synthesis of 2-aryl-substituted benzimidazoles and multicomponent synthesis of pyrimidines
    Kulkarni, Padmakar A.
    Kahandal, Sandeep S.
    Mirgane, Nitin A.
    Satpati, Ashis Kumar
    Shendage, Suresh S.
    [J]. RESULTS IN CHEMISTRY, 2022, 4
  • [43] Synthesis and Antimicrobial Activity of Some New 2,4,6-Trisubstituted Pyrimidines
    Prasad, Y. Rajendra
    Rao, B. Bhaskar
    Agarwal, N. K.
    Rao, A. Srinivasa
    [J]. ASIAN JOURNAL OF CHEMISTRY, 2011, 23 (02) : 641 - 644
  • [44] Synthesis and biological evaluation of new fused Isoxazolo[4',5':4,5] pyrano[2,3-d] Pyrimidines as potent anticancer agents
    Gopikishan, Tonukunuru
    Vana, Muralimohanarao
    Singh, Harbeer
    [J]. CHEMICAL BIOLOGY LETTERS, 2025, 12 (02):
  • [45] SYNTHESIS AND CALMING ACTIVITY OF 2-AMINO-4-(4-β-D-ALLOPYRANOSIDE-PHENYL)-6-3(4)-SUBSTITUTED PHENYLPYRIMIDINES
    Yin, XiuJuan
    Zheng, Lei
    Li, Ying
    Yin, ShuFan
    [J]. CHEMISTRY OF NATURAL COMPOUNDS, 2010, 46 (05) : 779 - 782
  • [46] Synthesis and calming activity of 2-amino-4-(4-β-d-allopyranoside-phenyl)-6-3(4)-substituted phenylpyrimidines
    XiuJuan Yin
    Lei Zheng
    Ying Li
    ShuFan Yin
    [J]. Chemistry of Natural Compounds, 2010, 46 : 779 - 782
  • [47] Synthesis and Hypolipidemic Activity of Novel 2-(4-(2-Amino-6-(4-Substituted Phenyl) Pyrimidin-4-yl)-2-Substituted Phenoxy) Acetic Acid Derivatives
    Mokale, Santosh N.
    Shete, Maheshwari T.
    Shaikh, Sameer I.
    Shinde, Devanand B.
    [J]. CHEMICAL BIOLOGY & DRUG DESIGN, 2012, 79 (04) : 548 - 552
  • [48] Synthesis, biological evaluation, and In silico molecular docking of N-(4-(4-substitutedphenyl)-6-(substituted aryl) pyrimidin-2-yl)-2-(2-isonicotinoyl hydrazinyl) acetamide
    Soni, Hetal I.
    Patel, Navin B.
    Ahmad, Iqrar
    Patel, Harun
    Rivera, Gildardo
    [J]. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2024, 38 (01)
  • [49] Solvent-free microwave-assisted synthesis of novel pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidines with potential antifungal activity
    Acosta, Paola
    Insuasty, Braulio
    Ortiz, Alejandro
    Abonia, Rodrigo
    Sortino, Maximiliano
    Zacchino, Susana A.
    Quiroga, Jairo
    [J]. ARABIAN JOURNAL OF CHEMISTRY, 2016, 9 (03) : 481 - 492
  • [50] Synthesis of new 4, 5-disubstituted-6-methyl-2-(methylthio) pyrimidines via C-C coupling reactions
    Cheldavi, Forough
    Bakherad, Mohammad
    Keivanloo, Ali
    Rezaeifard, Amin
    Nikpour, Mohsen
    [J]. JOURNAL OF SULFUR CHEMISTRY, 2024, 45 (05) : 690 - 702
12345