Synthesis of 4-pyrido-6-aryl-2-substituted amino pyrimidines as a new class of antimalarial agents

被引：37
作者：
Agarwal, A
Srivastava, K
Puri, SK
Chauhan, PMS [1 ]
机构：
[1] Cent Drug Res Inst, Div Med & Proc Chem, Lucknow 226001, Uttar Pradesh, India
[2] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 22期
关键词：
dihydrofolate reductase; antimalarial; pyrimidine;
D O I：
10.1016/j.bmc.2005.06.052
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of 2,4,6-trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds showed MIC in the range of 0.25-2 mu g/mL. These compounds are in vitro several fold more active than pyrimethamine.. (c) 2005 Published by Elsevier Ltd.
引用
收藏
页码：6226 / 6232
页数：7
相关论文
共 50 条
  • [21] Synthesis and Antimicrobial Activity of Some 2-Amino-4-(7-Substituted/Unsubstituted Coumarin-3-yl)-6-(Chlorosubstitutedphenyl) Pyrimidines
    Imran, Mohd
    Abida
    Khan, Suroor Ahmad
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2015, 14 (07) : 1265 - 1272
  • [22] Synthesis of 2-[3,5-substituted pyrazol-1-yl]-4,6-trisubstituted triazine derivatives as antimalarial agents
    Katiyar, SB
    Srivastava, K
    Puri, SK
    Chauhan, PMS
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (22) : 4957 - 4960
  • [23] Design and Synthesis of a New Class of 4-Aminoquinolinyl- and 9-Anilinoacridinyl Schiff Base Hydrazones as Potent Antimalarial Agents
    Sharma, Moni
    Chauhan, Kuldeep
    Srivastava, Rajeev K.
    Singh, Shiv V.
    Srivastava, Kumkum
    Saxena, Jitendra K.
    Puri, Sunil K.
    Chauhan, Prem M. S.
    CHEMICAL BIOLOGY & DRUG DESIGN, 2014, 84 (02) : 175 - 181
  • [24] Synthesis and characterization of new complexes derived from 4-thienyl substituted pyrimidines
    Cheprakova, Ekaterina M.
    Verbitskiy, Egor V.
    Kiskin, Mikhail A.
    Aleksandrov, Grigory G.
    Slepukhin, Pavel A.
    Sidorov, Aleksei A.
    Starichenko, Denis V.
    Shvachko, Yuri N.
    Eremenko, Igor L.
    Rusinov, Gennady L.
    Charushin, Valery N.
    POLYHEDRON, 2015, 100 : 89 - 99
  • [25] Synthesis and anticonvulsive activity of a series of new pyrano(thiopyrano,pyrido)-[4′,3′:4,5]thieno[2,3-d]pyrimidines
    Mkrtchyan A.P.
    Kazaryan S.G.
    Noravyan A.S.
    Dzhagatspanyan I.A.
    Nazaryan I.M.
    Akopyan A.G.
    Pharmaceutical Chemistry Journal, 1998, 32 (9) : 469 - 473
  • [26] Synthesis of new 4-aminoquinolines and quinoline-acridine hybrids as antimalarial agents
    Kumar, Ashok
    Srivastava, Kumkum
    Kumar, S. Raja
    Puri, S. K.
    Chauhan, Prem M. S.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (23) : 7059 - 7063
  • [27] Search for new pharmacophores for antimalarial activity. Part I: Synthesis and antimalarial activity of new 2-methyl-6-ureido-4-quinolinamides
    Madapa, S.
    Tusi, Z.
    Sridhar, D.
    Kumar, A.
    Siddiqi, M. I.
    Srivastava, K.
    Rizvi, A.
    Tripathi, R.
    Puri, S. K.
    Keshava, G. B. Shiva
    Shukla, P. K.
    Batra, S.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (01) : 203 - 221
  • [28] Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents
    Sandhu, Harmeet S.
    Sapra, Sameer
    Gupta, Mukesh
    Nepali, Kunal
    Gautam, Raju
    Yadav, Sunil
    Kumar, Raj
    Jachak, Sanjay M.
    Chugh, Manoj
    Gupta, Manish K.
    Suri, Om P.
    Dhar, K. L.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (15) : 5626 - 5633
  • [29] Synthesis, antiviral, antituberculostic, and antibacterial activities of some novel, 4-(4-substituted phenyl)-6-(4-nitrophenyl)-2-(substituted imino)pyrimidines
    Siddiqui, Anees A.
    Rajesh, Ramadoss
    Ul-Islam, Mojahid
    Alagarsamy, Veerachamy
    De Clercq, Erick
    ARCHIV DER PHARMAZIE, 2007, 340 (02) : 95 - 102
  • [30] Synthesis and biological evaluation of novel 5-aryl-4-(5-nitrofuran-2yl)-pyrimidines as potential anti-bacterial agents
    Verbitskiy, Egor V.
    Baskakova, Svetlana A.
    Gerasimova, Natal'ya A.
    Evstigneeva, Natal'ya P.
    Zil'berberg, Natal'ya V.
    Kungurov, Nikolay V.
    Kravchenko, Marionella A.
    Skornyakov, Sergey N.
    Pervova, Marina G.
    Rusinov, Gennady L.
    Chupakhin, Oleg N.
    Charushin, Valery N.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (13) : 3003 - 3006
12345