Synthesis of 4-pyrido-6-aryl-2-substituted amino pyrimidines as a new class of antimalarial agents

被引：37
|
作者：
Agarwal, A
Srivastava, K
Puri, SK
Chauhan, PMS [1 ]
机构：
[1] Cent Drug Res Inst, Div Med & Proc Chem, Lucknow 226001, Uttar Pradesh, India
[2] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 22期
关键词：
dihydrofolate reductase; antimalarial; pyrimidine;
D O I：
10.1016/j.bmc.2005.06.052
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of 2,4,6-trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds showed MIC in the range of 0.25-2 mu g/mL. These compounds are in vitro several fold more active than pyrimethamine.. (c) 2005 Published by Elsevier Ltd.
引用
收藏
页码：6226 / 6232
页数：7
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