Review Scopoletin - A Coumarin Phytoalexin with Medicinal Properties

被引：170
作者：
Gnonlonfin, G. J. Benoit [1 ,2 ,3 ]
Sanni, Ambaliou [3 ]
Brimer, Leon [1 ]
机构：
[1] Univ Copenhagen, Dept Vet Dis Biol, Fac Life Sci, DK-1870 Frederiksberg C, Denmark
[2] Natl Inst Agr Res Benin, Programme Agr & Food Technol, Porto Novo, Benin
[3] Univ Abomey Calavi, Biochem & Mol Biol Lab, Fac Sci & Tech, Cotonou, Benin
来源：
CRITICAL REVIEWS IN PLANT SCIENCES | 2012年 / 31卷 / 01期
关键词：
antifungal activity; biosynthesis; coumarins; scopoletin; distribution; CELL-SUSPENSION-CULTURES; POSTHARVEST PHYSIOLOGICAL DETERIORATION; TOBACCO TISSUE-CULTURES; MELILOTUS-ALBA DESR; ARABIDOPSIS-THALIANA; HEVEA-BRASILIENSIS; PHENOLIC COMPOUNDS; CASSAVA ROOTS; HEPATOPROTECTIVE ACTIVITY; INFLAMMATORY CYTOKINES;
D O I：
10.1080/07352689.2011.616039
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Coumarins have been found in many plant species and some have antimicrobial and antifungal activities as well as pharmacological effects. Scopoletin (6-methoxy-7-hydroxycoumarin) is a coumarin compound with antifungal properties that has been isolated from several plant species. Although it is not yet fully understood, the biosynthesis of scopoletin is described. In addition, its induction upon attack by pathogens and abiotic stress as well as its inhibitory effects on bacteria and fungi are summarized in this review. The scientific information on the inhibitory effect of scopoletin on storage fungi is scarce.
引用
收藏
页码：47 / 56
页数：10
相关论文
共 100 条
[1]  
ADESINA S K, 1982, International Journal of Crude Drug Research, V20, P93
[2]   Anthraquinones from Hedyotis capitellata [J].
Ahmad, R ;
Shaari, K ;
Lajis, NH ;
Hamzah, AS ;
Ismail, NH ;
Kitajima, M .
PHYTOCHEMISTRY, 2005, 66 (10) :1141-1147
[3]   Biosynthesis of scopoletin and scopolin in cassava roots during post-harvest physiological deterioration: The E-Z-isomerisation stage [J].
Bayoumi, Soad A. L. ;
Rowan, Michael G. ;
Blagbrough, Ian S. ;
Beeching, John R. .
PHYTOCHEMISTRY, 2008, 69 (17) :2928-2936
[4]   Investigation of Biosynthetic Pathways to Hydroxycoumarins During Post-Harvest Physiological Deterioration in Cassava Roots by Using Stable Isotope Labelling [J].
Bayoumi, Soad A. L. ;
Rowan, Michael G. ;
Beeching, John R. ;
Blagbrough, Ian S. .
CHEMBIOCHEM, 2008, 9 (18) :3013-3022
[5]  
Beeching JR, 1998, RECENT ADV PHYTOCHEM, V32, P231
[6]  
BEIER RC, 1990, REV ENV CONTAMINATIO, V113, P47
[7]   Confusion regarding anticoagulant coumarins in dietary supplements [J].
Booth, NL ;
Nikolic, D ;
van Breemen, RB ;
Geller, SE ;
Banuvar, S ;
Shulman, LP ;
Farnsworth, NR .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2004, 76 (06) :511-516
[8]   Biosynthesis of coumarins in plants: A major pathway still to be unravelled for cytochrome P450 enzymes [J].
Bourgaud F. ;
Hehn A. ;
Larbat R. ;
Doerper S. ;
Gontier E. ;
Kellner S. ;
Matern U. .
Phytochemistry Reviews, 2006, 5 (2-3) :293-308
[9]  
Broekaert WF, 1997, CRIT REV PLANT SCI, V16, P297, DOI 10.1080/713608148
[10]  
Brown S. A., 1981, The biochemistry of plants. A comprehensive treatise. Volume 7. Secondary plant products., P269
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