Neuroimmune alterations in the complex regional pain syndrome

被引：45

作者：

Huygen, FJPM ^{[1
]}

de Bruijn, AGJ ^{[1
]}

Klein, J ^{[1
]}

Zijlstra, FJ ^{[1
]}

机构：

[1] Erasmus Univ, Med Ctr, Hosp Dijkzigt, Dept Anaesthesiol, NL-3000 CA Rotterdam, Netherlands

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2001年 / 429卷 / 1-3期

关键词：

complex regional pain syndrome; neurogenic inflammation; pain; oedema; temperature; neuropeptide; cytokine; eicosanoid;

D O I：

10.1016/S0014-2999(01)01310-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review focuses on some clinical aspects of the complex regional pain syndrome, such as oedema, local temperature changes and chronic pain, as a result of supposed neurogenic inflammation. Involvement of the immune system could imply the subsequent release of neuropeptides, pro-inflammatory cytokines and eicosanoids, which in turn leads to a complex cross-talk of primary and secondary generated mediators of inflammation. The development and application of drugs that act through selective receptor antagonism or enzymatic synthesis inhibition to prevent further stimulation of this cascade that could inevitably lead to chronicity of this disease are extensively discussed. (C) 2001 Elsevier Science BN. All rights reserved.

引用

页码：101 / 113

页数：13

共 141 条

[41] alpha(1)-adrenoceptors in normal and hyperalgesic human skin [J].

Drummond, PD ;

Skipworth, S ;

Finch, PM .

CLINICAL SCIENCE, 1996, 91 (01) :73-77

[42] Innervation of hyperalgesic skin in patients with complex regional pain syndrome [J].

Drummond, PD ;

Finch, PM ;

Gibbins, I .

CLINICAL JOURNAL OF PAIN, 1996, 12 (03) :222-231

[43] Clinical outcome and pharmacokinetics after addition of low-dose cyclosporine to methotrexate: A case study of five patients with treatment-resistant inflammatory bowel disease [J].

Egan, LJ ;

Tremaine, WJ ;

Mays, DC ;

Lipsky, JJ ;

Sandborn, WJ .

INFLAMMATORY BOWEL DISEASES, 2000, 6 (04) :286-289

[44] INFLAMMATORY EFFECTS OF PROSTAGLANDIN D2 IN RAT AND HUMAN SKIN [J].

FLOWER, RJ ;

HARVEY, EA ;

KINGSTON, WP .

BRITISH JOURNAL OF PHARMACOLOGY, 1976, 56 (02) :229-233

[45] CASE-REPORTS AND HYPOTHESIS - A NEGLECT-LIKE SYNDROME MAY BE RESPONSIBLE FOR THE MOTOR DISTURBANCE IN REFLEX SYMPATHETIC DYSTROPHY (COMPLEX-REGIONAL-PAIN-SYNDROME-1) [J].

GALER, BS ;

BUTLER, S ;

JENSEN, MP .

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 1995, 10 (05) :385-391

[46] Time dependent production of cytokines and eicosanoids by human monocytic leukaemia U937 cells; effects of glucocorticosteroids [J].

Garrelds, IM ;

van Hal, PTW ;

Haakmat, RC ;

Hoogsteden, HC ;

Saxena, PR ;

Zijlstra, FJ .

MEDIATORS OF INFLAMMATION, 1999, 8 (4-5) :229-235

[47] Stressful life events and psychological dysfunction in complex regional pain syndrome type I [J].

Geertzen, JHB ;

de Bruijn-Kofman, AT ;

de Bruijn, HP ;

van de Wiel, HBM ;

Dijkstra, PU .

CLINICAL JOURNAL OF PAIN, 1998, 14 (02) :143-147

[48] SENSORY NEUROPEPTIDE RELEASE BY BRADYKININ - MECHANISMS AND PATHOPHYSIOLOGICAL IMPLICATIONS [J].

GEPPETTI, P .

REGULATORY PEPTIDES, 1993, 47 (01) :1-23

[49] Study of the analgesic effect of lanepitant in patients with osteoarthritis pain [J].

Goldstein, DJ ;

Wang, OH ;

Todd, LE ;

Gitter, BD ;

DeBrota, DJ ;

Iyengar, S .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2000, 67 (04) :419-426

[50] Molecular mechanisms involved in the regulation of prostaglandin biosynthesis by glucocorticoids [J].

GoppeltStruebe, M .

BIOCHEMICAL PHARMACOLOGY, 1997, 53 (10) :1389-1395

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