Neuroimmune alterations in the complex regional pain syndrome

被引：45

作者：

Huygen, FJPM ^{[1
]}

de Bruijn, AGJ ^{[1
]}

Klein, J ^{[1
]}

Zijlstra, FJ ^{[1
]}

机构：

[1] Erasmus Univ, Med Ctr, Hosp Dijkzigt, Dept Anaesthesiol, NL-3000 CA Rotterdam, Netherlands

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2001年 / 429卷 / 1-3期

关键词：

complex regional pain syndrome; neurogenic inflammation; pain; oedema; temperature; neuropeptide; cytokine; eicosanoid;

D O I：

10.1016/S0014-2999(01)01310-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review focuses on some clinical aspects of the complex regional pain syndrome, such as oedema, local temperature changes and chronic pain, as a result of supposed neurogenic inflammation. Involvement of the immune system could imply the subsequent release of neuropeptides, pro-inflammatory cytokines and eicosanoids, which in turn leads to a complex cross-talk of primary and secondary generated mediators of inflammation. The development and application of drugs that act through selective receptor antagonism or enzymatic synthesis inhibition to prevent further stimulation of this cascade that could inevitably lead to chronicity of this disease are extensively discussed. (C) 2001 Elsevier Science BN. All rights reserved.

引用

页码：101 / 113

页数：13

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