Palladium-catalyzed silyl C(sp3)-H bond activation

被引：39

作者：

Liang, Yun ^{[1
,2
,3
]}

Geng, Weizhi ^{[1
]}

Wei, Junnian ^{[1
]}

Ouyang, Kunbing ^{[1
]}

Xi, Zhenfeng ^{[1
,4
]}

机构：

[1] Peking Univ, Beijing Natl Lab Mol Sci, MOE Key Lab Bioorgan Chem & Mol Engn, Coll Chem, Beijing 100871, Peoples R China

[2] Hunan Normal Univ, Key Lab Resource Fine Proc & Adv Mat Hunan Prov, Coll Chem & Chem Engn, Changsha 410081, Hunan, Peoples R China

[3] Hunan Normal Univ, MOE Key Lab Chem Biol & Tradit Chinese Med Res, Coll Chem & Chem Engn, Changsha 410081, Hunan, Peoples R China

[4] CAS, SIOC, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 08期

关键词：

C-H BONDS; INTRAMOLECULAR ALKANE ARYLATION; SILICON-CARBON HETEROCYCLES; CROSS-COUPLING REACTIONS; MILD CONDITIONS; 6-MEMBERED SILACYCLES; METHYL-GROUPS; FUNCTIONALIZATION; ALPHA; SP(2);

D O I：

10.1039/c2ob06941e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first transition-metal-catalyzed activation of silyl C(sp(3))-H bond was realized and synthetically applied. A variety of organic skeletons substituted with SiMe3 groups could undergo the Pd-catalyzed intramolecular coupling reaction, resulting in an unprecedented synthetic method for yielding six-membered silacycles. It was found that the adjacent Si atom played an essential role for the activation of the C(sp(3))-H bond of the SiMe3 group; no activation reaction of the C(sp(3))-H bond of the CMe3 group took place under the same reaction conditions.

引用

页码：1537 / 1542

页数：6

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