Association of dairy consumption with metabolic syndrome, hypertension and diabetes in 147 812 individuals from 21 countries

被引：61

作者：

Bhavadharini, Balaji ^{[1
,2
]}

Dehghan, Mahshid ^{[1
,2
]}

Mente, Andrew ^{[1
,2
,3
]}

Rangarajan, Sumathy ^{[1
,2
]}

Sheridan, Patrick ^{[1
,2
]}

Mohan, Viswanathan ^{[4
,5
]}

Iqbal, Romaina ^{[6
]}

Gupta, Rajeev ^{[7
]}

Lear, Scott ^{[8
]}

Wentzel-Viljoen, Edelweiss ^{[9
]}

Avezum, Alvaro ^{[10
]}

Lopez-Jaramillo, Patricio ^{[11
]}

Mony, Prem ^{[12
]}

Varma, Ravi Prasad ^{[13
]}

Kumar, Rajesh ^{[14
]}

Chifamba, Jephat ^{[15
]}

Alhabib, Khalid F. ^{[16
]}

Mohammadifard, Noushin ^{[17
]}

Oguz, Aytekin ^{[18
]}

Lanas, Fernando ^{[19
]}

Rozanska, Dorota ^{[20
]}

Bostrom, Kristina Bengtsson ^{[21
]}

Yusoff, Khalid ^{[22
]}

Tsolkile, Lungiswa P. ^{[23
]}

Dans, Antonio ^{[24
]}

Yusufali, Afzalhussein ^{[25
]}

Orlandini, Andres ^{[26
]}

Poirier, Paul ^{[27
]}

Khatib, Rasha ^{[28
]}

Hu, Bo ^{[29
]}

Wei, Li ^{[30
]}

Yin, Lu ^{[29
]}

Deeraili, Ai ^{[31
]}

Yeates, Karen ^{[32
]}

Yusuf, Rita ^{[33
]}

Ismail, Noorhassim ^{[34
]}

Mozaffarian, Dariush ^{[35
]}

Teo, Koon ^{[1
,2
,3
,36
]}

Anand, Sonia S. ^{[1
,2
,3
,36
]}

Yusuf, Salim ^{[1
,2
,3
,36
]}

机构：

[1] Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada

[2] McMaster Univ, Hamilton, ON, Canada

[3] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada

[4] Madras Diabet Res Fdn, Epidemiol, Chennai, Tamil Nadu, India

[5] Dr Mohans Diabet Special Ctr Gopalapuram, Diabetol, Chennai, Tamil Nadu, India

[6] Aga Khan Univ, Karachi, Pakistan

[7] Eternal Heart Care Ctr & Res Inst, Prevent Cardiol, Jaipur, Rajasthan, India

[8] Simon Fraser Univ, Kinesiol, Burnaby, BC, Canada

[9] North West Univ, Potchefstroom, South Africa

[10] Dante Pazzanese Inst Cardiol, Res Div, Sao Paulo, Brazil

[11] Univ Santander, Bucaramanga, Colombia

[12] St Johns Med Coll & Res Inst, Bengaluru, Karnataka, India

[13] Achutha Menon Ctr Hlth Sci Studies, Thiruvananthapuram, Kerala, India

[14] Post Grad Inst Med Educ & Res, Chandigarh, India

[15] Univ Zimbabwe, Harare, Zimbabwe

[16] King Saud Univ, Riyadh, Riyadh Province, Saudi Arabia

[17] Isfahan Univ Med Sci, Esfahan, Iran

[18] Goztepe Training & Res Hosp, Internal Med, Istanbul, Marmara, Turkey

[19] Univ La Frontera, Temuco, Chile

[20] Wroclaw Med Univ, Wroclaw, Dolnoslaskie, Poland

[21] Univ Gothenburg, Gothenburg, Sweden

[22] Univ Teknol MARA, Shah Alam, Selangor, Malaysia

[23] Univ Western Cape, Bellville, South Africa

[24] Univ Philippines Syst, Quezon City, Metro Manila, Philippines

[25] Dubai Hlth Author, Dubai, U Arab Emirates

[26] Estudios Clin Latino Amer, Rosario, Argentina

[27] Inst Univ Cardiol & Pneumol Quebec, Cardiol, Quebec City, PQ, Canada

[28] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[29] Peking Union Med Coll, Sch Basic Med, Beijing, Peoples R China

[30] Chinese Acad Med Sci & Peking Union Med Coll, Med Res & Biometr Ctr, Fuwai Hosp, Beijing, Peoples R China

[31] Xinjiang Uighur Autonomous Reg Ctr Dis Control &, Urumqi, Xinjiang, Peoples R China

[32] Queens Univ, Kingston, ON, Canada

[33] Independent Univ, Dhaka, Bangladesh

[34] Univ Kebangsaan Malaysia, Bangi, Selangor, Malaysia

[35] Tufts Friedman Sch Nutr Sci & Policy, Boston, MA USA

[36] McMaster Univ, Dept Med, Hamilton, ON, Canada

来源：

BMJ OPEN DIABETES RESEARCH & CARE | 2020年 / 8卷 / 01期

基金：

瑞典研究理事会; 加拿大健康研究院;

关键词：

nutrition; hypertension; endocrinology; adult diabetes; DOSE-RESPONSE METAANALYSIS; LOW-INCOME COUNTRIES; CARDIOVASCULAR-DISEASE; LIFE-STYLE; BLOOD-PRESSURE; RISK; DIET; PURE; PREVENTION; NUTRIENTS;

D O I：

10.1136/bmjdrc-2019-000826

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective Our aims were to assess the association of dairy intake with prevalence of metabolic syndrome (MetS) (cross-sectionally) and with incident hypertension and incident diabetes (prospectively) in a large multinational cohort study. Methods The Prospective Urban Rural Epidemiology (PURE) study is a prospective epidemiological study of individuals aged 35 and 70 years from 21 countries on five continents, with a median follow-up of 9.1 years. In thecross-sectional analyses, we assessed the association of dairy intake with prevalent MetS and its components among individuals with information on the five MetS components (n=112 922). Forthe prospective analyses, we examined the association of dairy with incident hypertension (in 57 547 individuals free of hypertension) and diabetes (in 131 481 individuals free of diabetes). Results In cross-sectional analysis, higher intake of total dairy (at least two servings/day compared with zero intake; OR 0.76, 95% CI 0.71 to 0.80, p-trend<0.0001) was associated with a lower prevalence of MetS after multivariable adjustment. Higher intakes of whole fat dairy consumed alone (OR 0.72, 95% CI 0.66 to 0.78, p-trend<0.0001), or consumed jointly with low fat dairy (OR 0.89, 95% CI 0.80 to 0.98, p-trend=0.0005), were associated with a lower MetS prevalence. Low fat dairy consumed alone was not associated with MetS (OR 1.03, 95% CI 0.77 to 1.38, p-trend=0.13). In prospective analysis, 13 640 people with incident hypertension and 5351 people with incident diabetes were recorded. Higher intake of total dairy (at least two servings/day vs zero serving/day) was associated with a lower incidence of hypertension (HR 0.89, 95% CI 0.82 to 0.97, p-trend=0.02) and diabetes (HR 0.88, 95% CI 0.76 to 1.02, p-trend=0.01). Directionally similar associations were found for whole fat dairy versus each outcome. Conclusions Higher intake of whole fat (but not low fat) dairy was associated with alower prevalenceof MetS and most of its component factors, and with alower incidenceof hypertension and diabetes. Our findings should be evaluated in large randomized trials of the effects of whole fat dairy on the risks of MetS, hypertension, and diabetes.

引用

页数：12

共 37 条

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