Stereoselective reductive amination of chiral N,N-Dibenzylamino ketones

被引：9

作者：

Reetz, MT

Schmitz, A

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

[2] Univ Marburg, Fachbereich Chem, D-35043 Marburg, Germany

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 14期

关键词：

amino acids; diamines; asymmetric induction; reduction;

D O I：

10.1016/S0040-4039(99)00360-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N,N-Dibenzylamino ketones of the type Bn2N(R)CHC(O)CH3, prepared in enantiomerically pure form from alpha-amino acids, undergo stereoselective reductive amination using PhCH2NH2/NaCNBH3 or NH4OAc/NaCNBH3 with formation of diastereo- and enantiomerically pure vicinal diamines Bn2N(R)CHCH(NHCH2Ph)CH3 or Bn2N(R)CHCH(NH2)CH3, respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2741 / 2742

页数：2

共 18 条

[1] 2-AMINO-4-THIAZOLYL ACETIC-ACID DERIVATIVES OF CEPHALOSPORINS - EFFECT OF PRESENCE AND CONFIGURATION OF AN OXYIMINO GROUP ON ANTIBACTERIAL ACTIVITY [J].