Crosstalk Between Mammalian Autophagy and the Ubiquitin-Proteasome System

被引:300
作者
Kocaturk, Nur Mehpare [1 ]
Gozuacik, Devrim [1 ,2 ,3 ]
机构
[1] Sabanci Univ, Fac Engn & Nat Sci, Mol Biol Genet & Bioengn Program, Istanbul, Turkey
[2] Sabanci Univ, Ctr Excellence Funct Surfaces & Interfaces Nano D, Istanbul, Turkey
[3] Sabanci Univ, Nanotechnol Res & Applicat Ctr SUNUM, Istanbul, Turkey
来源
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2018年 / 6卷
关键词
autophagy; UPS; proteasome; ubiquitylation; protein quality control; mitophagy; proteostasis; organelle homeostasis; ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; TRANSCRIPTION FACTOR NRF2; REQUIRES DIRECT BINDING; SELECTIVE AUTOPHAGY; E3; LIGASE; CELL-DEATH; MYCOBACTERIUM-TUBERCULOSIS; MITOCHONDRIAL AUTOPHAGY; HUNTINGTIN FRAGMENTS;
D O I
10.3389/fcell.2018.00128
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Autophagy and the ubiquitin-proteasome system (UPS) are the two major intracellular quality control and recycling mechanisms that are responsible for cellular homeostasis in eukaryotes. Ubiquitylation is utilized as a degradation signal by both systems, yet, different mechanisms are in play. The UPS is responsible for the degradation of short-lived proteins and soluble misfolded proteins whereas autophagy eliminates long-lived proteins, insoluble protein aggregates and even whole organelles (e.g., mitochondria, peroxisomes) and intracellular parasites (e.g., bacteria). Both the UPS and selective autophagy recognize their targets through their ubiquitin tags. In addition to an indirect connection between the two systems through ubiquitylated proteins, recent data indicate the presence of connections and reciprocal regulation mechanisms between these degradation pathways. In this review, we summarize these direct and indirect interactions and crosstalks between autophagy and the UPS, and their implications for cellular stress responses and homeostasis.
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页数:27
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