Sweet's syndrome: study of 73 cases, emphasizing histopathological findings

被引:32
作者
Rochael, Mayra Carrijo [1 ]
Pantaleao, Luciana [1 ]
Guedes Vilar, Enoi A. [1 ]
Zacaron, Luciana Helena [1 ]
Spada, Eduardo Quelhas [1 ]
Xavier, Marcus H. S. B. [1 ]
Rodrigues, Karla Strong [1 ]
机构
[1] Univ Fed Fluminense, Hosp Univ Antonio Pedro, Dept Patol, Niteroi, RJ, Brazil
关键词
Erythema Multiforme; Hodgkin's Disease; Panniculitis; Sweet's Syndrome; FEBRILE NEUTROPHILIC DERMATOSIS; B-CELL LYMPHOMA; HODGKINS-DISEASE;
D O I
10.1590/S0365-05962011000400012
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
BACKGROUND: Sweet's syndrome refers to a set of cutaneous, systemic and histopathological alterations that occur in response to different stimuli, in a similar way to that occurring in erythema nodosum, erythema multiforme and leukocytoclastic vasculitis. The syndrome has been described in association with conditions such as infections, pregnancy, the use of certain medications and malignancy. OBJECTIVES: To evaluate the clinical and histopathological alterations occurring in this syndrome and to assess the association between these alterations and other conditions. METHODS: A retrospective study of 73 cases was conducted, evaluating data on the microscopic examination of skin lesions, as well as clinical and laboratory data. RESULTS: The majority of the patients were female (83.0%), white (49.2%) and between 30 and 60 years of age (73.8%). The principal alterations found were: erythymatous plaques (76.9%), papules (43.0%), pseudo-vesiculation (PV) (38.4%) and target lesions (18.5%). With respect to the associated conditions, upper respiratory tract infections (15.4%) and the use of medication (10.8%) were the most common. Other associations, albeit represented by only one case each, were: Hodgkin's lymphoma, pregnancy, ulcerative colitis, polycythemia vera and lupus erythematosus in a patient with acquired immune deficiency syndrome (AIDS). The principal microscopic findings were: neutrophils with leukocytoclasia (98.6%), collagen degeneration (87.7%), edema (74.0%) and PV (38.4%). The presence of eosinophils (41.1%) ranged from rare to abundant and was usually unrelated to the use of medication. Inflammatory infiltrate reached the deep epidermal layer in 47.9% of cases and panniculitis was found in 80.0% of cases in which the hypodermis was affected (10 cases). CONCLUSIONS: In general, these findings are in agreement with results published in the literature, emphasizing the frequent finding of eosinophils unrelated to drug use, panniculitis and the rare association with Hodgkin's lymphoma. This is the fifth report of an association between Sweet's syndrome and Hodgkin's disease.
引用
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页码:702 / 707
页数:6
相关论文
共 22 条
  • [1] ACKERMAN AB, 1997, HISTOLOGIC DIAGNOSIS, P740
  • [2] Histiocytoid neutrophilic dermatoses and panniculitides: Variations on a theme
    Chow, Stephen
    Pasternak, Sylvia
    Green, Peter
    Tremaine, Robert
    Reardon, Michael
    Murray, Scott
    Northgrave, Stacey
    Walsh, Noreen
    [J]. AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2007, 29 (04) : 334 - 341
  • [3] Sweet's syndrome - a comprehensive review of an acute febrile neutrophilic dermatosis
    Cohen, Philip R.
    [J]. ORPHANET JOURNAL OF RARE DISEASES, 2007, 2 (1)
  • [4] Sweet's syndrome revisited: a review of disease concepts
    Cohen, PR
    Kurzrock, R
    [J]. INTERNATIONAL JOURNAL OF DERMATOLOGY, 2003, 42 (10) : 761 - 778
  • [5] COHEN PR, ORPHANET ENCY
  • [6] Fitzgerald RL, 1996, INT J DERMATOL, V35, P9
  • [7] Franchini M, 2006, AM J HEMATOL, V81, P473, DOI 10.1590/S0365-05962006000500011
  • [8] Mycosis fungoides-type cutaneous T-cell lymphoma and neutrophilic dermatosis
    Franck, N
    Carlotti, A
    Gorin, I
    Buffet, M
    Mateus, C
    Dupin, N
    [J]. ARCHIVES OF DERMATOLOGY, 2005, 141 (03) : 353 - 356
  • [9] Sweet's syndrome on the area of postmastectomy lymphoedema
    García-Río, I
    Pérez-Gala, S
    Aragüés, M
    Fernández-Herrera, J
    Fraga, J
    García-Díez, A
    [J]. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2006, 20 (04) : 401 - 405
  • [10] Sweet's syndrome as initial presentation of diffuse large B-cell lymphoma
    Gille, J
    Spieth, K
    Kaufmann, R
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2002, 46 (02) : S11 - S13