Monitoring p53's pulse

被引:30
|
作者
Tyson, JJ [1 ]
机构
[1] Virginia Polytech Inst & State Univ, Blacksburg, VA 24061 USA
关键词
D O I
10.1038/ng0204-113
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The tumor-suppressor protein p53 mediates the response of mammalian cells to DNA damage. Studies now show that DNA damage elicits quantal pulses of p53, with greater damage eliciting more pulses.
引用
收藏
页码:113 / 114
页数:2
相关论文
共 50 条
  • [21] P53 mutations in Ewing's sarcoma
    Park, YK
    Chi, SG
    Kim, YW
    Park, HR
    Unni, KK
    ONCOLOGY REPORTS, 2001, 8 (03) : 533 - 537
  • [22] Regulation of p53 and p53 family members.
    Prives, C
    Ahn, J
    DiComo, C
    Gaiddon, C
    Shieh, S
    FASEB JOURNAL, 1999, 13 (07): : A1430 - A1430
  • [23] The p53 network: p53 and its downstream genes
    Shu, Kun-Xian
    Li, Biao
    Wu, Li-Xiang
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2007, 55 (01) : 10 - 18
  • [24] TRIMming p53's anticancer activity
    Elabd, S.
    Meroni, G.
    Blattner, C.
    ONCOGENE, 2016, 35 (43) : 5577 - 5584
  • [25] TRIMming p53’s anticancer activity
    S Elabd
    G Meroni
    C Blattner
    Oncogene, 2016, 35 : 5577 - 5584
  • [26] p53 protein and Kaposi's sarcoma
    Noel, JC
    Simonart, T
    AMERICAN JOURNAL OF DERMATOPATHOLOGY, 1998, 20 (03) : 322 - 322
  • [27] How the p53 mRNA controls p53 activity
    Malbert-Colas, Laurence
    Tournillon, Anne-Sophie
    Olivares-Illana, Vanesa
    Punnuswainy, Anand
    Fahraeus, Robin
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2012, 30 : S20 - S20
  • [28] Computational protein chemistry of p53 and p53 peptides
    Brandt-Rauf, PW
    Rosal, RV
    Fine, RL
    Pincus, MR
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2004, 9 : 2778 - 2787
  • [29] Digging deeper into p53's functions
    Sarah Seton-Rogers
    Nature Reviews Cancer, 2017, 17 : 706 - 706
  • [30] Digging deeper into p53's functions
    Seton-Rogers, Sarah
    NATURE REVIEWS CANCER, 2017, 17 (12) : 706 - 706