Neutrophil gelatinase-associated lipocalin in kidney transplantation: A review

被引：24

作者：

Ramirez-Sandoval, Juan C. ^{[1
]}

Herrington, William ^{[2
]}

Morales-Buenrostro, Luis E. ^{[1
]}

机构：

[1] Natl Inst Med Sci & Nutr Salvador, Dept Nephrol & Mineral Metab, Mexico City 14000, DF, Mexico

[2] Churchill Hosp, Oxford Univ Hosp NHS Trust, Oxford Kidney Unit, Oxford OX3 7LJ, England

来源：

TRANSPLANTATION REVIEWS | 2015年 / 29卷 / 03期

关键词：

DELAYED GRAFT FUNCTION; RENAL-ALLOGRAFT SURVIVAL; ACUTE REJECTION; PREDICTIVE BIOMARKERS; URINARY BIOMARKERS; EARLY MARKER; NGAL; INJURY; SERUM; RECOVERY;

D O I：

10.1016/j.trre.2015.04.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutrophil gelatinase-associated lipocalin (NGAL) is a protein expressed by kidney tubular cells in response to ischemia, but may also be an early indicator of immunological rejection, calcineurin inhibitor toxicity, obstructive nephropathy, subclinical tubulitis or infection. Although there is currently no evidence to support the routine serial measurement of blood or urinary NGAL to detect subclinical acute tubular injury, NGAL has the potential to provide useful information to those that care for kidney transplant recipients (KTRs). First, high urinary or serum NGAL concentrations shortly after transplantation are a predictor of delayed graft function and are associated with reduced graft function at one year. Secondly, among KTRs with previously stable graft function who then suffer acute graft dysfunction, a high urinary NGAL predicts graft loss at one year. If further refined, diagnostic tests based on NGAL levels may provide future useful clinical tools. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：139 / 144

页数：6

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