Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy

被引：313

作者：

Lu, Yuanjun ^{[1
]}

Chan, Yau-Tuen ^{[1
]}

Tan, Hor-Yue ^{[1
]}

Li, Sha ^{[1
]}

Wang, Ning ^{[1
]}

Feng, Yibin ^{[1
]}

机构：

[1] Univ Hong Kong, Sch Chinese Med, Pofulam, 10 Sassoon Rd, Hong Kong 000000, Peoples R China

来源：

MOLECULAR CANCER | 2020年 / 19卷 / 01期

关键词：

Epigenetic modification; Cancer; Epi-drugs; Combination strategy; Tumour microenvironment; HISTONE DEACETYLASE INHIBITOR; RANDOMIZED PHASE-II; DNA METHYLTRANSFERASE INHIBITOR; MESSENGER-RNA METHYLATION; ACUTE MYELOID-LEUKEMIA; LONG NONCODING RNAS; IN-VITRO; HEPATOCELLULAR-CARCINOMA; PROSTATE-CANCER; MESENCHYMAL TRANSITION;

D O I：

10.1186/s12943-020-01197-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epigenetics is dynamic and heritable modifications to the genome that occur independently of DNA sequence. It requires interactions cohesively with various enzymes and other molecular components. Aberrant epigenetic alterations can lead to inappropriate onset of genetic expressions and promote tumorigenesis. As the epigenetic modifiers are susceptible to extrinsic factors and reversible, they are becoming promising targets in multiple cancer therapies. Recently, various epi-drugs have been developed and implicated in clinical use. The use of epi-drugs alone, or in combination with chemotherapy or immunotherapy, has shown compelling outcomes, including augmentation of anti-tumoral effects, overcoming drug resistance, and activation of host immune response.

引用

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