Clostridioides difficile spore: coat assembly and formation

被引：9

作者：

Zeng, Ji ^{[1
]}

Wang, Hao ^{[1
]}

Dong, Min ^{[2
,3
]}

Tian, Guo-Bao ^{[4
,5
,6
,7
]}

机构：

[1] Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou, Peoples R China

[2] Harvard Med Sch, Dept Microbiol, Boston, MA 02115 USA

[3] Harvard Med Sch, Boston Childrens Hosp, Dept Urol, Boston, MA 02115 USA

[4] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, 74 Zhongshan 2nd Rd, Guangzhou 510080, Guangdong, Peoples R China

[5] Sun Yat Sen Univ, Affiliated Hosp 1, Adv Med Technol Ctr, Zhongshan Sch Med, Guangzhou, Peoples R China

[6] Sun Yat Sen Univ, Minist Educ, Key Lab Trop Dis Control, Guangzhou, Peoples R China

[7] Xizang Minzu Univ, Sch Med, Xianyang, Peoples R China

来源：

EMERGING MICROBES & INFECTIONS | 2022年 / 11卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Clostridioides difficile; sporulation; spore formation; coat assembly; morphogenetic protein; GLOBAL REGULATOR; EXOSPORIUM LAYER; SPORULATION; PROTEIN; CODY; VIRULENCE; IMMUNOGENICITY; MORPHOGENESIS; GERMINATION; ACTIVATION;

D O I：

10.1080/22221751.2022.2119168

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clostridioides difficile (C. difficile) is a Gram-positive, spore-forming, toxin-producing, obligate anaerobic bacterium. C. difficile infection (CDI) is the leading cause of healthcare-associated infective diarrhoea. The infection is mediated by the spore, a metabolically inactive form of C. difficile. The spore coat acts as a physical barrier to defend against chemical insults from hosts and natural environments. The composition of spore coat has already been revealed; therefore, the interactive networks of spore coat proteins and the dynamic process of coat assembly are the keys to design strategies to control and cure CDI. This review gives a brief discussion of the signal processing and transcriptional regulation of C. difficile sporulation initiation. Following the discussion, the spore formation is also introduced. Finally, this review mainly focuses on the spore coat assembly, a poorly understood process in C. difficile, and important proteins that have been studied.

引用

页码：2340 / 2349

页数：10

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