The essence of the engram: Cellular or synaptic?

被引：29

作者：

Han, Dae Hee ^{[1
]}

Park, Pojeong ^{[1
]}

Choi, Dong Il ^{[1
]}

Bliss, Tim V. P. ^{[2
]}

Kaang, Bong-Kiun ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Nat Sci, Sch Biol Sci, Seoul 08826, South Korea

[2] Francis Crick Inst, 1 Midland Rd, London NW1 1AT, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2022年 / 125卷

关键词：

Engram cells; Synaptic engram; Cellular consolidation; Systems consolidation; Reconsolidation; Extinction; LONG-TERM POTENTIATION; ANTERIOR CINGULATE CORTEX; IMMEDIATE-EARLY GENES; FEAR MEMORY; DENDRITIC SPINES; NMDA RECEPTOR; RETROGRADE-AMNESIA; CONTEXTUAL FEAR; C-FOS; RAT HIPPOCAMPUS;

D O I：

10.1016/j.semcdb.2021.05.033

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Memory is composed of various phases including cellular consolidation, systems consolidation, reconsolidation, and extinction. In the last few years it has been shown that simple association memories can be encoded by a subset of the neuronal population called engram cells. Activity of these cells is necessary and sufficient for the recall of association memory. However, it is unclear which molecular mechanisms allow cellular engrams to encode the diverse phases of memory. Further research is needed to examine the possibility that it is the synapses between engram cells (the synaptic engram) that constitute the memory. In this review we summarize recent findings on cellular engrams with a focus on different phases of memory, and discuss the distinct molecular mechanism required for cellular and synaptic engrams.

引用

页码：122 / 135

页数：14

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