Gut dysbiosis in Spondyloarthritis: Cause or effect?

被引:13
作者
Mauro, Daniele [1 ]
Ciccia, Francesco [1 ]
机构
[1] Univ Campania L Vanvitelli, Dept Precis Med, Naples, Italy
来源
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2019年 / 33卷 / 06期
关键词
Spondyloarthritis; Dysbiosis; Gut inflammation; Intestinal permeability; ANKYLOSING-SPONDYLITIS; REACTIVE ARTHRITIS; FECAL MICROBIOTA; METAGENOMICS; AUTOIMMUNITY; INFLAMMATION; ACTIVATION; DIVERSITY; GENETICS; THERAPY;
D O I
10.1016/j.berh.2020.101493
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Spondyloarthritis (SpA) is a group of chronic, inflammatory rheumatic diseases mainly affecting the axial skeleton. Although the pathogenesis of the disease remains elusive, alterations of intestinal microbial composition have been demonstrated in patients with SpA and associated with intestinal and systemic immune alterations. Substantial data have been published in recent years in ethnically different patient populations, demonstrating in a consolidated way the presence of alterations in the composition of the microbial flora in patients with SpA. It is not currently possible to establish whether these alterations are intrinsically inherent in the disease, for example, the effect of particular genes that confer susceptibility to the disease itself, or are a consequence of a more systemic inflammatory process that also involves the intestine. However, data deriving from animal models and studies on relatives of patients with SpA strongly suggest that these alterations might precede the onset of the disease. In this review, we will try to critically analyze studies on dysbiosis in SpA and animal models of SpA, analyzing their functional consequences and the impact of biotechnological therapies on intestinal bacterial composition. (C) 2020 Elsevier Ltd. All rights reserved.
引用
收藏
页数:10
相关论文
共 55 条
[51]   The Virome in Mammalian Physiology and Disease [J].
Virgin, Herbert W. .
CELL, 2014, 157 (01) :142-150
[52]   Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitis [J].
Wen, Chengping ;
Zheng, Zhijun ;
Shao, Tiejuan ;
Liu, Lin ;
Xie, Zhijun ;
Le Chatelier, Emmanuelle ;
He, Zhixing ;
Zhong, Wendi ;
Fan, Yongsheng ;
Zhang, Linshuang ;
Li, Haichang ;
Wu, Chunyan ;
Hu, Changfeng ;
Xu, Qian ;
Zhou, Jia ;
Cai, Shunfeng ;
Wang, Dawei ;
Huang, Yun ;
Breban, Maxime ;
Qin, Nan ;
Ehrlich, Stanislav Dusko .
GENOME BIOLOGY, 2017, 18
[53]   Monocyte anergy in septic shock is associated with a predilection to apoptosis and is reversed by granulocyte-macrophage colony-stimulating factor ex vivo [J].
Williams, MA ;
Withington, S ;
Newland, AC ;
Kelsey, SM .
JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (05) :1421-1433
[54]   Shotgun metagenomics reveals an enrichment of potentially cross-reactive bacterial epitopes in ankylosing spondylitis patients, as well as the effects of TNFi therapy upon microbiome composition [J].
Yin, Jian ;
Sternes, Peter Richard ;
Wang, Mingbang ;
Song, Jing ;
Morrison, Mark ;
Li, Ting ;
Zhou, Ling ;
Wu, Xin ;
He, Fusheng ;
Zhu, Jian ;
Brown, Matthew A. ;
Xu, Huji .
ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 (01) :132-140
[55]   Metagenomic profiling of the pro-inflammatory gut microbiota in ankylosing spondylitis [J].
Zhou, Chen ;
Zhao, Hui ;
Xiao, Xin-yue ;
Chen, Bei-di ;
Guo, Rui-jin ;
Wang, Qi ;
Chen, Hua ;
Zhao, Li-dan ;
Zhang, Chen-chen ;
Jiao, Yu-hao ;
Ju, Yan-mei ;
Yang, Hua-xia ;
Fei, Yun-yun ;
Wang, Li ;
Shen, Min ;
Li, Hui ;
Wang, Xiao-han ;
Lu, Xin ;
Yang, Bo ;
Liu, Jin-jing ;
Li, Jing ;
Peng, Lin-yi ;
Zheng, Wen-jie ;
Zhang, Chun-yan ;
Zhou, Jia-xin ;
Wu, Qing-jun ;
Yang, Yun-jiao ;
Su, Jin-mei ;
Shi, Qun ;
Wu, Di ;
Zhang, Wen ;
Zhang, Feng-chun ;
Jia, Hui-jue ;
Liu, De-pei ;
Jie, Zhu-ye ;
Zhang, Xuan .
JOURNAL OF AUTOIMMUNITY, 2020, 107