Role of Main RNA Methylation in Hepatocellular Carcinoma: N6-Methyladenosine, 5-Methylcytosine, and N1-Methyladenosine

被引：36

作者：

Xu, Yating ^{[1
,2
,3
,4
]}

Zhang, Menggang ^{[1
,2
,3
,4
]}

Zhang, Qiyao ^{[1
,2
,3
,4
]}

Yu, Xiao ^{[1
,2
,3
,4
]}

Sun, Zongzong ^{[5
]}

He, Yuting ^{[1
,2
,3
,4
]}

Guo, Wenzhi ^{[1
,2
,3
,4
]}

机构：

[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Hepatobiliary & Pancreat Surg, Zhengzhou, Peoples R China

[2] Zhengzhou Univ, Affiliated Hosp 1, Key Lab Hepatobiliary & Pancreat Surg & Digest Or, Zhengzhou, Peoples R China

[3] Open & Key Lab Hepatobiliary & Pancreat Surg & Di, Zhengzhou, Peoples R China

[4] Henan Key Lab Digest Organ Transplantat, Zhengzhou, Peoples R China

[5] Zhengzhou Univ, Affiliated Hosp 3, Dept Obstet & Gynaecol, Zhengzhou, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

基金：

中国国家自然科学基金;

关键词：

hepatocellular carcinoma; RNA methylation; M6A; m5C; m1A; MESSENGER-RNA; NONCODING RNA; RIBOSOMAL-RNA; M(6)A; METHYLTRANSFERASE; READERS; IDENTIFICATION; EXPRESSION; REVEALS; WRITERS;

D O I：

10.3389/fcell.2021.767668

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

RNA methylation is considered a significant epigenetic modification, a process that does not alter gene sequence but may play a necessary role in multiple biological processes, such as gene expression, genome editing, and cellular differentiation. With advances in RNA detection, various forms of RNA methylation can be found, including N6-methyladenosine (m6A), N1-methyladenosine (m1A), and 5-methylcytosine (m5C). Emerging reports confirm that dysregulation of RNA methylation gives rise to a variety of human diseases, particularly hepatocellular carcinoma. We will summarize essential regulators of RNA methylation and biological functions of these modifications in coding and noncoding RNAs. In conclusion, we highlight complex molecular mechanisms of m6A, m5C, and m1A associated with hepatocellular carcinoma and hope this review might provide therapeutic potent of RNA methylation to clinical research.

引用

页数：10

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