An Additional Coordination Group Leads to Extremely Efficient Chiral Iridium Catalysts for Asymmetric Hydrogenation of Ketones

被引：214
作者：
Xie, Jian-Hua [1 ,2 ]
Liu, Xiao-Yan [1 ,2 ]
Xie, Jian-Bo [1 ,2 ]
Wang, Li-Xin [1 ,2 ]
Zhou, Qi-Lin [1 ,2 ]
机构：
[1] Nankai Univ, State Key Lab, Tianjin 300071, Peoples R China
[2] Nankai Univ, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 32期
基金：
中国国家自然科学基金;
关键词：
asymmetric catalysis; chiral alcohols; hydrogenation; iridium; ketones; HIGHLY ENANTIOSELECTIVE HYDROGENATION; IR-DIPHOSPHINE CATALYSTS; COMPLEXES; LIGANDS; QUINOLINES; SWITCH; SCALE;
D O I：
10.1002/anie.201102710
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
What a turnover! An efficient chiral iridium catalyst that bears a tridentate spiro aminophosphine ligand catalyzes the asymmetric hydrogenation of ketones with excellent enantioselectivities (up to 99.9 % ee) and extremely high turnover numbers (TONs; as high as 4 550 000). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：7329 / 7332
页数：4
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