Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy

被引：515

作者：

Feng, Yangbo ^{[1
]}

Xiong, Yanlu ^{[1
]}

Qiao, Tianyun ^{[1
]}

Li, Xiaofei ^{[1
]}

Jia, Lintao ^{[2
]}

Han, Yong ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Tangdu Hosp, Dept Thorac Surg, Xian, Shaanxi, Peoples R China

[2] Fourth Mil Med Univ, Dept Biochem & Mol Biol, State Key Lab Canc Biol, Xian, Shaanxi, Peoples R China

来源：

CANCER MEDICINE | 2018年 / 7卷 / 12期

基金：

中国国家自然科学基金;

关键词：

cancer; glycolysis; lactate; LDHA; metabolism; SERUM LACTIC-DEHYDROGENASE; A-SUBUNIT GENE; LDH-A; GASTRIC-CANCER; HEPATOCELLULAR-CARCINOMA; CELL-PROLIFERATION; AEROBIC GLYCOLYSIS; TUMOR PROGRESSION; RESPONSE ELEMENTS; COLORECTAL-CANCER;

D O I：

10.1002/cam4.1820

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Elevated glycolysis remains a universal and primary character of cancer metabolism, which deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) facilitates glycolytic process by converting pyruvate to lactate. Numerous researches demonstrate LDHA has an aberrantly high expression in multiple cancers, which is associated with malignant progression. In this review, we summarized LDHA function in cancer research. First, we gave an introduction of structure, location, and basic function of LDHA. Following, we discussed the transcription and activation mode of LDHA. Further, we focused on the function of LDHA in cancer bio-characteristics. Later, we discussed the clinical practice of LDHA in cancer prevention and treatment. What we discussed gives a precise insight into LDHA especially in cancer research, which will contribute to exploring cancer pathogenesis and its handling measures.

引用

页码：6124 / 6136

页数：13

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