Thymic output and peripheral T lymphocyte subsets in relapsing-remitting multiple sclerosis patients treated or not by IFN-β

被引：14
作者：
Puissant-Lubrano, Benedicte [1 ,2 ]
Viala, Frederique
Winterton, Peter [2 ]
Abbal, Michel [1 ,2 ]
Clanet, Michel
Blancher, Antoine [1 ,2 ]
机构：
[1] CHU Toulouse, Hop Rangueil, Immunol Lab, F-31059 Toulouse 9, France
[2] Univ Toulouse 3, Fac Med Toulouse Rangueil, Immunogenet Mol Lab, F-31062 Toulouse 4, France
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 193卷 / 1-2期
关键词：
multiple sclerosis; thymic function; regulatory T cells; IFN-beta treatment; T cell subsets; CD45RC;
D O I：
10.1016/j.jneuroim.2007.10.027
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We explored the parameters of central and peripheral tolerance in patients with stable relapsing-remitting multiple sclerosis, treated or not with IFN-beta TREC-positive T cells were lower in patients compared with controls, mainly in CD4+ subset, compatible with a thymus dysfunction or an expansion of peripheral lymphocytes. Compared to controls, the frequency of activated CD4+CD25+ T cells was higher in patients without modification of the CD4+CD25(high) T cell proportion. The IFN-beta-treatment did not modify the TREC-positive cell frequency nor the naive/memory T cell subset percentage but was associated with lower blood lymphocyte count and a lower frequency of CD4+CD45RC(high) subset. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：188 / 194
页数：7
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