Current Usage and Future Directions for the Bovine Pericardial Patch

被引:137
作者
Li, Xin [1 ,2 ,3 ]
Guo, Yuanyuan [1 ,2 ,3 ]
Ziegler, Kenneth R. [1 ,2 ]
Model, Lynn S. [1 ,2 ]
Eghbalieh, Sammy D. D. [2 ,4 ]
Brenes, Robert A. [2 ,4 ]
Kim, Susun T. [1 ,2 ]
Shu, Chang [3 ]
Dardik, Alan [1 ,2 ,5 ]
机构
[1] Yale Univ, Sch Med, Dept Surg, New Haven, CT 06520 USA
[2] Yale Univ, Sch Med, Interdept Program Vasc Biol & Therapeut, New Haven, CT 06520 USA
[3] Cent S Univ, Dept Vasc Surg, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
[4] St Marys Hosp, Stanley J Dudrick Dept Surg, Waterbury, CT USA
[5] VA Connecticut Healthcare Syst, West Haven, CT USA
关键词
CAROTID-ENDARTERECTOMY; TISSUE REGENERATION; IN-VITRO; ARTERY ENDARTERECTOMY; VEIN PATCH; CALCIFICATION; ANGIOPLASTY; CELLS; GRAFT; COMPLICATION;
D O I
10.1016/j.avsg.2010.11.007
中图分类号
R61 [外科手术学];
学科分类号
摘要
Bovine pericardium (BP) is widely used in surgery and is commonly used as a patch after arteriotomy in cardiovascular surgery. BP patches have several advantages compared with prosthetic patches, including superior biocompatability, easy handling, less suture line bleeding, and possibly reduced rates of infection. These advantages of BP have led to its common use during carotid endarterectomy (CEA). However, long-term clinical results reported after CEA have suggested several issues that may be related to the patch, including restenosis, pseudoaneurysm formation, infection, fibrosis, calcification, and thrombosis. These complications may diminish the long-term efficacy of CEA and suggest potential areas for improvement of surgical patches. Understanding the mechanisms by which BP heals after patch angioplasty may lead to next generation tissue-engineered patches.
引用
收藏
页码:561 / 568
页数:8
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