The crystal structure of a llama heavy chain variable domain

被引：131
作者：
Spinelli, S
Frenken, L
Bourgeois, D
deRon, L
Bos, W
Verrips, T
Anguille, C
Cambillau, C
Tegoni, M
机构：
[1] CNRS UPR 9039,F-13402 MARSEILLE 20,FRANCE
[2] UNILEVER RES LABS,NL-3133 AT VLAARDINGEN,NETHERLANDS
[3] EUROPEAN SYNCHROTRON RADIAT FACIL,F-38043 GRENOBLE,FRANCE
来源：
NATURE STRUCTURAL BIOLOGY | 1996年 / 3卷 / 09期
关键词：
D O I：
10.1038/nsb0996-752
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The 1.85 Å structure of an antigen-free llama heavy chain variable domain reveals a fold similarity to that of the classical immunoglobulin VHs, increased surface hydrophilicity of the side of the VH corresponding to that facing the VL domain in classical immunoglobulins, and alterations in the pattern of the CDRs.
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收藏
页码：752 / 757
页数：6
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