Total Synthesis of (±)-Aspidophylline A

被引：128

作者：

Zu, Liansuo ^{[1
]}

Boal, Ben W. ^{[1
]}

Garg, Neil K. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 23期

基金：

美国国家科学基金会;

关键词：

STEREOCONTROLLED SYNTHESIS; HECK REACTION; ALKALOIDS; STRYCHNOS; KOPSIA;

D O I：

10.1021/ja203227q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the total synthesis of (+/-)-aspidophylline A, one of many complex furoindoline-containing alkaloids that has not been synthesized previously. Our route features a number of key transformations, including a Heck cyclization to assemble the [3.3.1]-bicyclic scaffold as well as a late-stage interrupted Fischer indolization to install the furoindoline and construct the natural product's pentacyclic framework.

引用

页码：8877 / 8879

页数：3

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