Mechanisms and Therapeutic Regulation of Pyroptosis in Inflammatory Diseases and Cancer

被引：156
作者：
Zheng, Zhaodi [1 ]
Li, Guorong [1 ]
机构：
[1] Shandong Normal Univ, Sch Life Sci, Shandong Prov Key Lab Anim Resistant, Jinan 250014, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 04期
基金：
中国国家自然科学基金;
关键词：
pyroptosis; GSDMD; GSDME; inflammatory disease; cancer therapy; CELL-DEATH PATHWAYS; GASDERMIN D; HEPATOCYTE PYROPTOSIS; INHIBITS PYROPTOSIS; INDUCE PYROPTOSIS; APOPTOSIS; ACTIVATION; CASPASE-11; GSDMD; INFLAMMASOMES;
D O I：
10.3390/ijms21041456
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Programmed Cell Death (PCD) is considered to be a pathological form of cell death when mediated by an intracellular program and it balances cell death with survival of normal cells. Pyroptosis, a type of PCD, is induced by the inflammatory caspase cleavage of gasdermin D (GSDMD) and apoptotic caspase cleavage of gasdermin E (GSDME). This review aims to summarize the latest molecular mechanisms about pyroptosis mediated by pore-forming GSDMD and GSDME proteins that permeabilize plasma and mitochondrial membrane activating pyroptosis and apoptosis. We also discuss the potentiality of pyroptosis as a therapeutic target in human diseases. Blockade of pyroptosis by compounds can treat inflammatory disease and pyroptosis activation contributes to cancer therapy.
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页数：16
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