Incidence and prevalence of tuberculosis in systemic lupus erythematosus patients: A systematic review and meta-analysis

被引:12
作者
Wu, Qian [1 ]
Liu, Yang [2 ]
Wang, Wei [1 ]
Zhang, Yu [1 ]
Liu, Kui [1 ]
Chen, Song-Hua [1 ]
Chen, Bin [1 ]
机构
[1] Zhejiang Prov Ctr Dis Control & Prevent, Dept TB Control & Prevent, Hangzhou, Peoples R China
[2] Jiaxing Ctr Dis Control & Prevent, Dept Infect Dis Control & Prevent, Jiaxing, Peoples R China
关键词
systemic lupus erythematosus; tuberculosis; incidence; prevalence; glucocorticoids; RISK-FACTORS; INFECTIONS; PULMONARY; HOSPITALIZATIONS; SPECTRUM; DISEASES; COHORT; SLE;
D O I
10.3389/fimmu.2022.938406
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
BackgroundSystemic lupus erythematosus (SLE) patients are particularly susceptible to infections, such as pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB). This meta-analysis aimed to determine the incidence and prevalence of tuberculosis (TB) in SLE patients. MethodsThe Web of Science, PubMed, Cochrane Library, and Chinese National Knowledge Infrastructure databases were searched for articles of relevant studies published from the dates the databases were established until April 30, 2022. The I-2 statistic and Q test were used to evaluate heterogeneity among the analysed studies. Random-effects models were utilised and subgroup analyses were conducted for analysis of the study data. ResultsA total of 35 studies with 46,327 SLE patients were eligible for analysis. The incidence and prevalence of TB among the SLE patients were 1.16 per 100 person-years (95% confidence interval (CI): 0.69-1.93) and 3.59% (95% CI: 2.57%-5.02%), respectively. The pooled prevalence of SLE-PTB and SLE-EPTB was 2.46% (95% CI: 1.73%-3.51%) and 1.42% (95% CI: 0.98%-2.06%), respectively. Subgroup analyses showed that the incidence of SLE-TB was higher in Africa and in countries with a high TB burden than in countries with a low TB burden. The prevalence of SLE-TB was elevated in Asia, in patients taking a mean daily dose of glucocorticoids >= 20 mg, in studies with small sample sizes (n <1000) and ended before 2001. ConclusionsThe available evidence suggests that both the incidence and prevalence of TB in SLE patients are high. This study provides a more specific understanding of SLE-TB, which can help health policymakers in the development of preventive strategies for reducing the SLE-TB burden.
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页数:9
相关论文
共 45 条
[1]  
Ahmmed M F, 2019, Mymensingh Med J, V28, P797
[2]   Factors associated with active tuberculosis in Colombian patients with systemic lupus erythematosus: a case-control study [J].
Alonso Gonzalez-Naranjo, Luis ;
Alberto Coral-Enriquez, Jaime ;
Restrepo-Escobar, Mauricio ;
Horacio Munoz-Vahos, Carlos ;
Jaramillo-Arroyave, Daniel ;
Lucia Vanegas-Garcia, Adriana ;
Eraso, Ruth ;
Vasquez, Gloria ;
Jaimes, Fabian .
CLINICAL RHEUMATOLOGY, 2021, 40 (01) :181-191
[3]   Active and Latent Tuberculosis in Patients With Systemic Lupus Erythematosus Living in the United States [J].
Chu, Alvina D. ;
Polesky, Andrea H. ;
Bhatia, Gulshan ;
Bush, Thomas M. .
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 2009, 15 (05) :226-229
[4]   Spectrum of infections and outcome among hospitalized South Africans with systemic lupus erythematosus [J].
Dubula, Thozama ;
Mody, Girish M. .
CLINICAL RHEUMATOLOGY, 2015, 34 (03) :479-488
[5]   High risk of tuberculosis in systemic lupus erythematosus? [J].
Erdozain, JG ;
Ruiz-Irastorza, G ;
Egurbide, MV ;
Martinez-Berriotxoa, A ;
Aguirre, C .
LUPUS, 2006, 15 (04) :232-235
[6]   TUBERCULOSIS IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS [J].
FENG, PH ;
TAN, TH .
ANNALS OF THE RHEUMATIC DISEASES, 1982, 41 (01) :11-14
[7]  
Font CV, 2003, REV CLIN ESP, V203, P178, DOI 10.1157/13045537
[8]   Serious infections in British patients with systemic lupus erythematosus: hospitalisations and mortality [J].
Goldblatt, F. ;
Chambers, S. ;
Rahman, A. ;
Isenberg, D. A. .
LUPUS, 2009, 18 (08) :682-689
[9]   Tuberculosis in a cohort of patients with systemic lupus erythematosus [J].
Gonzalez Leon, Rocio ;
Garrido Rasco, Rocio ;
Chinchilla Palomares, Eduardo ;
Garcia Hernandez, Francisco Jose ;
Jesus Castillo Palma, M. ;
Sanchez Roman, Julio .
REUMATOLOGIA CLINICA, 2010, 6 (05) :256-261
[10]  
Gupta Latika, 2021, Mediterr J Rheumatol, V32, P134, DOI 10.31138/mjr.32.2.134