In vitro susceptibility of methicillin-resistant Staphylococcus aureus and methicillin-susceptible Staphylococcus aureus to a new antimicrobial, copper silicate

被引：13
作者：
Carson, Kerry C.
Bartlett, Jessica G.
Tan, Trina-Jean
Riley, Thomas V.
机构：
[1] Div Microbiol & Infect Dis, PathWest Lab Med WA, Nedlands, WA 6909, Australia
[2] Univ Western Australia, Dept Microbiol & Immunol, Nedlands, WA 6009, Australia
[3] Queen Elizabeth Med Ctr 2, Nedlands, WA 6009, Australia
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 12期
关键词：
D O I：
10.1128/AAC.00771-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The soluble copper silicate (CS) MIC of 100 strains of methicillin-resistant Staphylococcus aureus and 100 strains of methicillin-susceptible S. aureus (MSSA) was 175 mg Cu/liter. Bactericidal and postantibiotic effects (2:1 h) were seen at 2x MIC and 4x MIC. The frequency of mutation was <10(-9), and serial passage could not extend growth beyond 1.6x MIC.
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页码：4505 / 4507
页数：3
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