Palladium-Catalyzed Synthesis of 2,3-Disubstituted Benzothiophenes via the Annulation of Aryl Sulfides with Alkynes

被引：53

作者：

Masuya, Yoshihiro ^{[1
]}

Tobisu, Mamoru ^{[2
]}

Chatani, Naoto ^{[1
]}

机构：

[1] Osaka Univ, Dept Appl Chem, Fac Engn, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Engn, Ctr Atom & Mol Technol, Suita, Osaka 5650871, Japan

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 17期

关键词：

C-H ACTIVATION; ESTROGEN-RECEPTOR MODULATORS; CARBON-SILICON BOND; RADICAL CYCLIZATION; INTERNAL ALKYNES; VISIBLE-LIGHT; HETEROCYCLES; CLEAVAGE; DERIVATIVES; PERFORMANCE;

D O I：

10.1021/acs.orglett.6b02055

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method has been developed for the synthesis of 2,3-disubstituted benzothiophenes involving the palladium-catalyzed annulation of aryl sulfides with alkynes. This convergent approach exhibited good functional group tolerance, providing rapid access to a diverse array of derivatives from simple, readily available starting materials. This protocol can also be used to synthesize 2-silyl-substituted benzothiophenes, which can be used as versatile platforms for the synthesis of 2,3-unsymmetrically substituted benzothiophenes.

引用

页码：4312 / 4315

页数：4

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