Neuropeptides in sensory signal processing

被引：20

作者：

Carr, Richard ^{[1
]}

Frings, Stephan ^{[2
]}

机构：

[1] Heidelberg Univ, Med Fac Mannheim, Dept Expt Pain Res, Ludolf Krehl Str 13-17, D-68167 Mannheim, Germany

[2] Heidelberg Univ, Dept Anim Physiol, Ctr Organismal Studies, Heidelberg, Germany

来源：

CELL AND TISSUE RESEARCH | 2019年 / 375卷 / 01期

关键词：

Neuropeptide; Sensory; Trigeminal; Chemesthesis; CGRP; GENE-RELATED-PEPTIDE; IMMUNOREACTIVE NERVE-FIBERS; SOLITARY CHEMOSENSORY CELLS; SPIRAL MODIOLAR ARTERY; HUMAN NASAL-MUCOSA; SUBSTANCE-P; TRIGEMINAL MODULATION; FUNGIFORM PAPILLAE; CGRP RECEPTORS; BLOOD-VESSELS;

D O I：

10.1007/s00441-018-2946-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Peptides released from trigeminal fibers fulfill well-understood functions in neuroinflammatory processes and in the modulation of nociceptive signal processing. In particular, calcitonin gene-related peptide (CGRP) and substance P (SP), released from afferent nerve terminals, exert paracrine effects on the surrounding tissue and this has been recently highlighted by the prominent parcrinerole of CGRPin the development of headache and migraine. Some recent communications suggest that these sensory neuropeptides may also modulate the workings of sensory organs and influence afferent signals from nose, tongue, eyes and ears. Here, we briefly review the evidence for modulatory effects of CGRP and SP in the sensory periphery.

引用

页码：217 / 225

页数：9

共 122 条

[1] Transient receptor potential cation channel subfamily V member 1 expressing corneal sensory neurons can be subdivided into at least three subpopulations [J].

Alamri, Abdulhakeem ;

Bron, Romke ;

Brock, James A. ;

Ivanusic, Jason J. .

FRONTIERS IN NEUROANATOMY, 2015, 9

[2] IMMUNOREACTIVE NERVE-FIBERS IN THE NASAL-MUCOSA - AN EXPERIMENTAL-STUDY ON NEUROPEPTIDES-Y, CALCITONIN GENE-RELATED PEPTIDE AND GALANIN [J].

AMORES, AE ;

SPREKELSEN, C ;

BERNALSPREKELSEN, M .

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 1991, 248 (08) :487-491

[3] An immunohistochemical screening of neurochemical markers in fungiform papillae and taste buds of the anterior rat tongue [J].

Astback, J ;

Arvidson, K ;

Johansson, O .

ARCHIVES OF ORAL BIOLOGY, 1997, 42 (02) :137-147

[4] NEUROPEPTIDES IN THE RESPIRATORY-TRACT .2. [J].

BARNES, PJ ;

BARANIUK, JN ;

BELVISI, MG .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (06) :1391-1399

[5]

BECKERS HJM, 1992, INVEST OPHTH VIS SCI, V33, P1979

[6] Neural basis of sensation in intact and injured corneas [J].

Belmonte, C ;

Acosta, MC ;

Gallar, J .

EXPERIMENTAL EYE RESEARCH, 2004, 78 (03) :513-525

[7] Vasoactive intestinal and calcitonin gene-related peptides, tyrosine hydroxylase and nitrergic markers in the innervation of the rat central retinal artery [J].

Bergua, A ;

Schrödl, F ;

Neuhuber, WL .

EXPERIMENTAL EYE RESEARCH, 2003, 77 (03) :367-374

[8] Distribution of CGRP and its receptor components CLR and RAMP1 in the rat retina [J].

Blixt, Frank W. ;

Radziwon-Balicka, Aneta ;

Edvinsson, Lars ;

Warfvinge, Karin .

EXPERIMENTAL EYE RESEARCH, 2017, 161 :124-131

[9]

BORTOLAMI R, 1991, BRAIN RES, V547, P82

[10] Olfactory/trigeminal interactions in nasal chemoreception [J].

Brand, Gerard .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2006, 30 (07) :908-917

← 1 2 3 4 5 6 7 8 9 10 →