A Simple Synthetic Route to Well-Defined [Pd(NHC)Cl(1-tBu-indenyl)] Pre-catalysts for Cross-Coupling Reactions

被引：11

作者：

Liu, Yaxu ^{[1
,2
]}

Scattolin, Thomas ^{[1
,2
]}

Gobbo, Alberto ^{[1
,2
]}

Belis, Marek ^{[1
,2
]}

Van Hecke, Kristof ^{[1
,2
]}

Nolan, Steven P. ^{[1
,2
]}

Cazin, Catherine S. J. ^{[1
,2
]}

机构：

[1] Univ Ghent, Dept Chem, Krijgslaan 281,S-3, B-9000 Ghent, Belgium

[2] Univ Ghent, Ctr Sustainable Chem, Krijgslaan 281,S-3, B-9000 Ghent, Belgium

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2022年 / 2022卷 / 01期

基金：

比利时弗兰德研究基金会;

关键词：

Buchwald-Hartwig amination; N-heterocyclic carbene ligands; Palladium indenyl complexes; Suzuki-Miyaura cross-coupling; Weak base route; SUZUKI-MIYAURA REACTION; HETEROCYCLIC CARBENE COMPLEXES; (NHC)PD(ALLYL)CL NHC; GENERAL-METHOD; PD-PEPPSI; C-N; PRECATALYST; LIGANDS; PD(I); REACTIVITY;

D O I：

10.1002/ejic.202100840

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The development of robust, more efficient, general, easily accessible Pd(II)-NHC pre-catalysts remains a key issue in cross-coupling applications. A selection of well-defined, air and moisture stable [Pd(NHC)Cl(1-Bu-t-indenyl)] (NHC=IPr, IPrCl, IMes, SIMes, IPr*) pre-catalysts have been synthesized in good to excellent yields by reacting [Pd(1-Bu-t-indenyl)(mu-Cl)](2) and various NHC.HCl precursors in the presence of the weak base K2CO3 in green acetone. The synthesized Pd(II)-NHC derivatives displayed excellent catalytic activity in classical Suzuki-Miyaura and Buchwald-Hartwig reactions, especially when IPrCl is employed as ancillary ligand. Additionally, in the challenging Suzuki-Miyaura reaction between esters and arylboronic acids, the [Pd(IPr*)Cl(1-Bu-t-indenyl)] complex exhibited the optimum catalytic activity under very mild reaction conditions.

引用

页数：8

共 57 条

[1] Single-Step Synthesis of Dinuclear Neutral Gold(I) Complexes with Bridging Di(N-heterocyclic carbene) Ligands and Their Catalytic Performance in Cross Coupling Reactions and Alkyne Hydroamination [J].