The sweet and sour of cancer: Glycans as novel therapeutic targets

被引：1123
作者：
Fuster, MM
Esko, JD [1 ]
机构：
[1] Univ Calif San Diego, Dept Cellular & Mol Med, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Med, Div Pulm & Crit Care Med, La Jolla, CA 92093 USA
来源：
NATURE REVIEWS CANCER | 2005年 / 5卷 / 07期
关键词：
D O I：
10.1038/nrc1649
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A growing body of evidence supports crucial roles for glycans at various pathophysiological steps of tumour progression. Glycans regulate tumour proliferation, invasion, haematogenous metastasis and angiogenesis, and increased understanding of these roles sets the stage for developing pharmaceutical agents that target these molecules. Such novel agents might be used alone or in combination with operative and/ or chemoradiation strategies for treating cancer.
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页码：526 / 542
页数：17
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