The sweet and sour of cancer: Glycans as novel therapeutic targets

被引：1131
作者：
Fuster, MM
Esko, JD [1 ]
机构：
[1] Univ Calif San Diego, Dept Cellular & Mol Med, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Med, Div Pulm & Crit Care Med, La Jolla, CA 92093 USA
来源：
NATURE REVIEWS CANCER | 2005年 / 5卷 / 07期
关键词：
D O I：
10.1038/nrc1649
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A growing body of evidence supports crucial roles for glycans at various pathophysiological steps of tumour progression. Glycans regulate tumour proliferation, invasion, haematogenous metastasis and angiogenesis, and increased understanding of these roles sets the stage for developing pharmaceutical agents that target these molecules. Such novel agents might be used alone or in combination with operative and/ or chemoradiation strategies for treating cancer.
引用
收藏
页码：526 / 542
页数：17
相关论文
共 159 条
[1]   Suppression of invasive behavior of melanoma cells by stable expression of anti-sense perlecan cDNA [J].
Adatia, R ;
Albini, A ;
Carlone, S ;
Giunciuglio, D ;
Benelli, R ;
Santi, L ;
Noonan, DM .
ANNALS OF ONCOLOGY, 1997, 8 (12) :1257-1261
[2]   Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis [J].
Al-Mehdi, AB ;
Tozawa, K ;
Fisher, AB ;
Shientag, L ;
Lee, A ;
Muschel, RJ .
NATURE MEDICINE, 2000, 6 (01) :100-102
[3]  
Almofti A, 2004, INT J ONCOL, V25, P65
[4]   Polysialyltransferases: major players in polysialic acid synthesis on the neural cell adhesion molecule [J].
Angata, K ;
Fukuda, M .
BIOCHIMIE, 2003, 85 (1-2) :195-206
[5]  
[Anonymous], 1995, The molecular basis of cancer
[6]   CD44 IS THE PRINCIPAL CELL-SURFACE RECEPTOR FOR HYALURONATE [J].
ARUFFO, A ;
STAMENKOVIC, I ;
MELNICK, M ;
UNDERHILL, CB ;
SEED, B .
CELL, 1990, 61 (07) :1303-1313
[7]   Histopathological subtypes and prognosis of gastric cancer are correlated with the expression of mucin-associated sialylated antigens:: Sialosyl-Lewisa, sialosyl-Lewisx and sialosyl-Tn [J].
Baldus, SE ;
Zirbes, TK ;
Mönig, SP ;
Engel, S ;
Monaca, E ;
Rafiqpoor, K ;
Hanisch, FG ;
Hanski, C ;
Thiele, J ;
Pichlmaier, H ;
Dienes, HP .
TUMOR BIOLOGY, 1998, 19 (06) :445-453
[8]   Syndecans in tumor cell adhesion and signaling [J].
Beauvais D.M. ;
Rapraeger A.C. .
Reproductive Biology and Endocrinology, 2 (1)
[9]   The syndecan-1 ectodomain regulates αvβ3 integrin activity in human mammary carcinoma cells [J].
Beauvais, DLM ;
Burbach, BJ ;
Rapraeger, AC .
JOURNAL OF CELL BIOLOGY, 2004, 167 (01) :171-181
[10]   Tumor attenuation by combined heparan sulfate and polyamine depletion [J].
Belting, M ;
Borsig, L ;
Fuster, MM ;
Brown, JR ;
Persson, L ;
Fransson, LÅ ;
Esko, JD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (01) :371-376
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