Fatigue Is Associated With Global and Regional Thalamic Morphometry in Veterans With a History of Mild Traumatic Brain Injury

被引:21
作者
Clark, Alexandra L. [1 ,2 ]
Sorg, Scott F. [2 ,4 ]
Holiday, Kelsey [1 ,2 ]
Bigler, Erin D. [5 ,6 ,7 ]
Bangen, Katherine J. [2 ,4 ]
Evangelista, Nicole D. [2 ]
Bondi, Mark W. [2 ,4 ]
Schiehser, Dawn M. [2 ,3 ,4 ]
Delano-Wood, Lisa [2 ,3 ,4 ]
机构
[1] San Diego State Univ Univ Calif San Diego SDSU UC, San Diego, CA USA
[2] VASDHS, San Diego, CA USA
[3] VA San Diego Healthcare Syst, Ctr Excellence Stress & Mental Hlth, San Diego, CA USA
[4] Univ Calif San Diego, Sch Med, Dept Psychiat, 9500 Gillman Dr, La Jolla, CA 92093 USA
[5] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA
[6] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA
[7] Brigham Young Univ, Neurosci Ctr, Provo, UT 84602 USA
基金
美国国家卫生研究院;
关键词
central fatigue; fatigue; mild traumatic brain injury; mTBI; thalamic morphometry; thalamic shape; thalamic volume; thalamus; Veterans; 1ST; 2; YEARS; COGNITIVE FATIGUE; VOLUME; INTEGRITY; SYMPTOMS; IMPACT; INFLAMMATION; CONNECTIVITY; ATROPHY; NUCLEI;
D O I
10.1097/HTR.0000000000000377
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: Fatigue is a complex, multidimensional phenomenon that commonly occurs following traumatic brain injury (TBI). The thalamusa structure vulnerable to both primary and secondary injuries in TBIis thought to play a pivotal role in the manifestation of fatigue. We explored how neuroimaging markers of local and global thalamic morphometry relate to the subjective experience of fatigue post-TBI. Methods: Sixty-three Veterans with a history of mild TBI underwent structural magnetic resonance imaging and completed questionnaires related to fatigue and psychiatric symptoms. FMRIB's Software (FSL) was utilized to obtain whole brain and thalamic volume estimates, as well as to perform regional thalamic morphometry analyses. Results: Independent of age, sex, intracranial volume, posttraumatic stress disorder, and depressive symptoms, greater levels of self-reported fatigue were significantly associated with decreased right (P = .026) and left (P = .046) thalamic volumes. Regional morphometry analyses revealed that fatigue was significantly associated with reductions in the anterior and dorsomedial aspects of the right thalamic body (P < .05). Similar trends were observed for the left thalamic body (P < .10). Conclusions: Both global and regional thalamic morphometric changes are associated with the subjective experience of fatigue in Veterans with a history of mild TBI. These findings support a theory in which disruption of thalamocorticostriatal circuitry may result in the manifestation of fatigue in individuals with a history of neurotrauma.
引用
收藏
页码:382 / 392
页数:11
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