Cassane-type diterpenes from roots of Pterolobium macropterum and their anti-inflammatory activity

被引：7

作者：

Raksat, Achara ^{[1
]}

Choodej, Siwattra ^{[1
]}

Aree, Thammarat ^{[1
]}

Ebrahimi, Samad Nejad ^{[2
]}

Pudhom, Khanitha ^{[1
]}

机构：

[1] Chulalongkorn Univ, Fac Sci, Dept Chem, Bangkok 10330, Thailand

[2] Shahid Beheshti Univ, Med Plants & Drugs Res Inst, Dept Phytochem, Tehran, Iran

来源：

PHYTOCHEMISTRY | 2022年 / 196卷

关键词：

Pterolobium macropterum; Leguminosae; Cassane diterpenes; Pterolobirins; Nitric oxide production; SEEDS;

D O I：

10.1016/j.phytochem.2021.113074

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eight undescribed cassane diterpenes, pterolobirins C-J, together with two known analogs, were isolated from the roots of Pterolobium macropterum. Their structures were characterized by extensive spectroscopic techniques including NMR, MS, ECD and X-ray crystallographic spectroscopy. The absolute configuration of pterolobirin J was confirmed by single-crystal X-ray diffraction data. The compounds were screened for their anti-inflammatory activity on the lipopolysaccharide (LPS) induced nitric oxide (NO) production in J774. A1 macrophage cells. Pterolobirin E and sucutinirane C displayed good NO inhibition with IC50 values of 24.44 +/- 1.34 and 19.16 +/- 1.22 mu M, respectively.

引用

页数：8

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