The role of indoxyl sulfate in renal anemia in patients with chronic kidney disease

被引：29

作者：

Wu, Chih-Jen ^{[1
,2
,3
,4
]}

Chen, Cheng-Yi ^{[1
]}

Lai, Thung-S. ^{[5
]}

Wu, Pei-Chen ^{[1
]}

Chuang, Chih-Kuang ^{[6
,7
,8
]}

Sun, Fang-Ju ^{[9
,10
]}

Liu, Hsuan-Liang ^{[6
]}

Chen, Han-Hsiang ^{[1
,9
]}

Yeh, Hung-I. ^{[11
]}

Lin, Chih-Sheng ^{[12
]}

Lin, Cheng-Jui ^{[1
,6
,9
]}

机构：

[1] Mackay Mem Hosp, Div Nephrol, Dept Internal Med, Mackay Med Coll, Taipei, Taiwan

[2] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung, Taiwan

[3] Taipei Med Univ, Grad Inst Med Sci, Taipei, Taiwan

[4] Taipei Med Univ, Dept Pharmacol, Sch Med, Coll Med, Taipei, Taiwan

[5] Mackay Med Coll, Grad Inst Biomed Sci, New Taipei, Taiwan

[6] Natl Taipei Univ Technol, Inst Biotechnol, Taipei, Taiwan

[7] Mackay Mem Hosp, Dept Med Res, Dept Genet & Metab, Taipei, Taiwan

[8] Fu Jen Catholic Univ, Coll Med, Taipei, Taiwan

[9] Mackay Jr Coll Med Nursing & Management, Taipei, Taiwan

[10] Mackay Mem Hosp, Dept Med Res, Taipei, Taiwan

[11] Mackay Med Coll, Dept Med, New Taipei, Taiwan

[12] Natl Chaio Tung Univ, Dept Biol Sci & Technol, Hsinchu, Taiwan

来源：

ONCOTARGET | 2017年 / 8卷 / 47期

关键词：

indoxyl sulfate; chronic kidney disease; erythropoietin; renal anemia; BOUND UREMIC TOXINS; HEMODIALYSIS-PATIENTS; ERYTHROPOIETIN PRODUCTION; FAILURE; STRESS; PROGRESSION; SUPPRESSES; TOXICITY; HYPOXIA; RISK;

D O I：

10.18632/oncotarget.18789

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Renal anemia is a common complication in patients with advanced chronic kidney disease. In vitro studies have shown that indoxyl sulfate decreases erythropoietin production. Whether this effect is seen in vivo remains unclear. Our goal was to explore the role of indoxyl sulfate in renal anemia. We found serum indoxyl sulfate levels are significantly and negatively associated with erythropoietin levels in human. A multiple stepwise linear regression analyses after adjustment for other independent parameters revealed that free indoxyl sulfate, and total indoxyl sulfate were significantly associated with erythropoietin levels. In animal studies, erythropoietin gene and protein expression were markedly inhibited in rats with chronic kidney disease; however, this effect was significantly reversed by lowering serum indoxyl sulfate with AST-120. Indoxyl sulfate may also inhibit erythropoietin expression in animal models with chronic kidney disease. These findings further support the role of indoxyl sulfate in the development of renal anemia.

引用

页码：83030 / 83037

页数：8

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