Non-Coding RNAs in Adrenocortical Cancer: From Pathogenesis to Diagnosis

被引：18
作者：
Decmann, Abel [1 ]
Perge, Pal [1 ]
Turai, Peter Istvan [1 ]
Patocs, Attila [2 ,3 ,4 ]
Igaz, Peter [1 ,5 ]
机构：
[1] Semmelweis Univ, Fac Med, Dept Internal Med 2, Szentkiralyi Str 46, H-1088 Budapest, Hungary
[2] MTA SE Lendulet Hereditary Endocrine Tumors Res G, H-1089 Budapest, Hungary
[3] Semmelweis Univ, Dept Lab Med, H-1089 Budapest, Hungary
[4] Natl Inst Oncol, Dept Mol Genet, H-1122 Budapest, Hungary
[5] MTA SE Mol Med Res Grp, H-1088 Budapest, Hungary
来源：
CANCERS | 2020年 / 12卷 / 02期
关键词：
non-coding RNA; microRNA; lncRNA; adrenocortical cancer; biomarker; GROWTH-FACTOR-II; GENOME-WIDE ANALYSIS; CIRCULATING MICRORNAS; EXPRESSION; GENE; TUMORS; TISSUE; CARCINOMA; MARKERS; SERUM;
D O I：
10.3390/cancers12020461
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Non-coding RNA molecules including microRNAs and long non-coding RNAs (lncRNA) have been implicated in the pathogenesis of several tumors and numerous data support their applicability in diagnosis as well. Despite recent advances, the pathogenesis of adrenocortical cancer still remains elusive and there are no reliable blood-borne markers of adrenocortical malignancy, either. Several findings show the potential applicability of microRNAs as biomarkers of malignancy and prognosis, and there are some data on lncRNA as well. In this review, we present a synopsis on the potential relevance of non-coding RNA molecules in adrenocortical pathogenesis and their applicability in diagnosis from tissue and blood.
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页数：17
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