Heme oxygenase-1 induction by nitric oxide in RAW 264.7 macrophages is upregulated by a cyclo-oxygenase-2 inhibitor

被引：33
|
作者：
Alcaraz, MJ [1 ]
Habib, A
Créminon, C
Vincente, AM
Lebret, M
Lévy-Toledano, S
Maclouf, J
机构：
[1] Univ Valencia, Dept Pharmacol, E-46100 Valencia, Spain
[2] Inst Fed Rech Lariboisiere Paris 7, INSERM, Unite 348, F-75475 Paris 10, France
[3] CEA, Serv Pharmacol & Immunol, Dept Rech Med, F-91191 Gif Sur Yvette, France
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2001年 / 1526卷 / 01期
关键词：
heme oxygenase; nitric oxide; macrophage; non-steroidal anti-inflammatory drug;
D O I：
10.1016/S0304-4165(01)00112-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Unstimulated RAW 264.7 macrophages express negligible heme oxygenase-1 (HO-1) protein but incubation with the nitric oxide (NO) donor spermine nonoate (SPNO) induced HO-1 and weakly cyclo-oxygenase-2 (COX-2) protein. This effect was potentiated by coincubation with the COX-2 selective inhibitor. SC58125. Cells incubated with SPNO showed a strong increase in HO-1 mRNA levels after 4 h with a significant potentiation in the presence of SC58125, which did not modify HO-1 mRNA stability. The induction of HO-1 by NO and its potentiation by anti-inflammatory agents may play a role in inflammatory and immune responses. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：13 / 16
页数：4
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