Heme oxygenase-1 induction by nitric oxide in RAW 264.7 macrophages is upregulated by a cyclo-oxygenase-2 inhibitor

被引：33
作者：
Alcaraz, MJ [1 ]
Habib, A
Créminon, C
Vincente, AM
Lebret, M
Lévy-Toledano, S
Maclouf, J
机构：
[1] Univ Valencia, Dept Pharmacol, E-46100 Valencia, Spain
[2] Inst Fed Rech Lariboisiere Paris 7, INSERM, Unite 348, F-75475 Paris 10, France
[3] CEA, Serv Pharmacol & Immunol, Dept Rech Med, F-91191 Gif Sur Yvette, France
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2001年 / 1526卷 / 01期
关键词：
heme oxygenase; nitric oxide; macrophage; non-steroidal anti-inflammatory drug;
D O I：
10.1016/S0304-4165(01)00112-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Unstimulated RAW 264.7 macrophages express negligible heme oxygenase-1 (HO-1) protein but incubation with the nitric oxide (NO) donor spermine nonoate (SPNO) induced HO-1 and weakly cyclo-oxygenase-2 (COX-2) protein. This effect was potentiated by coincubation with the COX-2 selective inhibitor. SC58125. Cells incubated with SPNO showed a strong increase in HO-1 mRNA levels after 4 h with a significant potentiation in the presence of SC58125, which did not modify HO-1 mRNA stability. The induction of HO-1 by NO and its potentiation by anti-inflammatory agents may play a role in inflammatory and immune responses. (C) 2001 Elsevier Science B.V. All rights reserved.
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页码：13 / 16
页数：4
相关论文
共 20 条
  • [1] TRANSFECTION OF THE HUMAN HEME OXYGENASE GENE INTO RABBIT CORONARY MICROVESSEL ENDOTHELIAL-CELLS - PROTECTIVE EFFECT AGAINST HEME AND HEMOGLOBIN TOXICITY
    ABRAHAM, NG
    LAVROVSKY, Y
    SCHWARTZMAN, ML
    STOLTZ, RA
    LEVERE, RD
    GERRITSEN, ME
    SHIBAHARA, S
    KAPPAS, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (15) : 6798 - 6802
  • [2] THE PHYSIOLOGICAL SIGNIFICANCE OF HEME OXYGENASE
    ABRAHAM, NG
    LIN, JHC
    SCHWARTZMAN, ML
    LEVERE, RD
    SHIBAHARA, S
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1988, 20 (06): : 543 - &
  • [3] Enhanced expression of haem oxygenase-1 by nitric oxide and antiinflammatory drugs in NIH 3T3 fibroblasts
    Alcaraz, MJ
    Habib, A
    Lebret, M
    Créminon, C
    Lévy-Toledano, S
    Maclouf, J
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2000, 130 (01) : 57 - 64
  • [4] Nitric oxide-inducible expression of heme oxygenase-1 in human cells - Translation-independent stabilization of the mRNA and evidence for direct action of nitric oxide
    Bouton, C
    Demple, B
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (42) : 32688 - 32693
  • [5] Callejas NA, 1999, J PHARMACOL EXP THER, V288, P1235
  • [6] Chan CC, 1999, J PHARMACOL EXP THER, V290, P551
  • [7] DIFFERENTIAL MEASUREMENT OF CONSTITUTIVE (COX-1) AND INDUCIBLE (COX-2) CYCLOOXYGENASE EXPRESSION IN HUMAN UMBILICAL VEIN ENDOTHELIAL-CELLS USING SPECIFIC IMMUNOMETRIC ENZYME IMMUNOASSAYS
    CREMINON, C
    HABIB, A
    MACLOUF, J
    PRADELLES, P
    GRASSI, J
    FROBERT, Y
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1995, 1254 (03): : 341 - 348
  • [8] KAGEYAMA H, 1988, CANCER RES, V48, P4795
  • [9] Nitric oxide and macrophage function
    MacMicking, J
    Xie, QW
    Nathan, C
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 : 323 - 350
  • [10] DOES CARBON-MONOXIDE HAVE A PHYSIOLOGICAL-FUNCTION
    MARKS, GS
    BRIEN, JF
    NAKATSU, K
    MCLAUGHLIN, BE
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (05) : 185 - 188
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