Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells

被引：17

作者：

Tripathi, Sudipta ^{[1
]}

Chabtini, Lola ^{[1
]}

Dakle, Pranal J. ^{[1
]}

Smith, Brian ^{[1
]}

Akiba, Hisaya ^{[2
]}

Yagita, Hideo ^{[2
]}

Guleria, Indira ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Div Renal, Childrens Hosp Boston, Boston, MA 02163 USA

[2] Juntendo Univ, Dept Immunol, Tokyo, Japan

来源：

PLOS ONE | 2015年 / 10卷 / 04期

基金：

美国国家卫生研究院;

关键词：

NATURAL-KILLER-CELLS; METRIAL GLAND-CELLS; INNATE IMMUNE CELLS; CHRONIC HEPATITIS-B; SUPPRESSOR-CELLS; RECEPTORS; PREGNANCY; DIFFERENTIATION; REPERTOIRE; MICE;

D O I：

10.1371/journal.pone.0123439

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

NK cells are the most abundant lymphocyte population in the feto-maternal interface during gestation. The uterine NK cells (uNK) are transient, have a unique immunophenotype and produce a number of cytokines. These cytokines play an important role in establishment and maintenance of vascular remodeling and tolerance associated with successful pregnancy. The uNK cells also express TIM-3 during gestation and blockade of TIM-3 expression results in fetal loss in mice. In this study we determined the effect of TIM-3 blockade on uNK cells. Specifically we observed surface receptor phenotype and cytokine production by uNK cells following TIM-3 blockade. Our results show that TIM-3 plays a role in regulating the uNK cells and contributes to the maintenance of tolerance at the feto-maternal interface.

引用

页数：19

共 41 条

[1] Tim-3, a negative regulator of anti-tumor immunity [J].

Anderson, Ana Carrizosa .

CURRENT OPINION IN IMMUNOLOGY, 2012, 24 (02) :213-216

[2] Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy [J].

Ashkar, AA ;

Black, GP ;

Wei, QX ;

He, H ;

Liang, LC ;

Head, JR ;

Croy, BA .

JOURNAL OF IMMUNOLOGY, 2003, 171 (06) :2937-2944

[3] The uterine NK cell population requires IL-15 but these cells are not required for pregnancy nor the resolution of a Listeria monocytogenes infection [J].

Barber, EM ;

Pollard, JW .

JOURNAL OF IMMUNOLOGY, 2003, 171 (01) :37-46

[4] Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells [J].

Carlyle, James R. ;

Mesci, Aruz ;

Ljutic, Belma ;

Belanger, Simon ;

Tai, Lee-Hwa ;

Rousselle, Etienne ;

Troke, Angela D. ;

Proteau, Marie-France ;

Makrigiannis, Andrew P. .

JOURNAL OF IMMUNOLOGY, 2006, 176 (12) :7511-7524

[5] TIM-3 Regulates Innate Immune Cells To Induce Fetomaternal Tolerance [J].

Chabtini, Lola ;

Mfarrej, Bechara ;

Mounayar, Marwan ;

Zhu, Bing ;

Batal, Ibrahim ;

Dakle, Pranal J. ;

Smith, Brian D. ;

Boenisch, Olaf ;

Najafian, Nader ;

Akiba, Hisaya ;

Yagita, Hideo ;

Guleria, Indira .

JOURNAL OF IMMUNOLOGY, 2013, 190 (01) :88-96

[6] Maternal KIR and fetal HLA-C: a fine balance [J].

Chazara, Olympe ;

Xiong, Shiqiu ;

Moffett, Ashley .

JOURNAL OF LEUKOCYTE BIOLOGY, 2011, 90 (04) :703-716

[7] Reproductive immunology [J].

Christiansen, Ole B. .

MOLECULAR IMMUNOLOGY, 2013, 55 (01) :8-15

[8]

Croy BA, 2006, IMMUNOL REV, V214, P161

[9] Imaging of Vascular Development in Early Mouse Decidua and Its Association with Leukocytes and Trophoblasts [J].

Croy, B. Anne ;

Chen, Zhilin ;

Hofmann, Alexander P. ;

Lord, Edith M. ;

Sedlacek, Abigail L. ;

Gerber, Scott A. .

BIOLOGY OF REPRODUCTION, 2012, 87 (05)

[10]

DAMJANOV A, 1992, J REPROD FERTIL, V95, P679

← 1 2 3 4 5 →