Gadolinium-porphyrin based polymer nanotheranostics for fluorescence/magnetic resonance imaging guided photodynamic therapy

被引：24

作者：

Chen, Wandi ^{[1
]}

Zhao, Junkai ^{[1
]}

Hou, Mengfei ^{[1
]}

Yang, Mo ^{[2
]}

Yi, Changqing ^{[1
,3
]}

机构：

[1] Sun Yat Sen Univ, Guangdong Prov Engn & Technol Ctr Adv & Portable, Sch Biomed Engn, Shenzhen 518107, Peoples R China

[2] Hong Kong Polytech Univ, Dept Biomed Engn, Hong Kong, Peoples R China

[3] Sun Yat Sen Univ Shenzhen, Res Inst, Shenzhen 518057, Peoples R China

来源：

NANOSCALE | 2021年 / 13卷 / 38期

关键词：

CARBON QUANTUM DOTS; SINGLET OXYGEN GENERATION; MULTIFUNCTIONAL NANOPARTICLES; FACILE SYNTHESIS; CANCER; MECHANISM; NANOSENSOR; NANODOTS; PLATFORM; DESIGN;

D O I：

10.1039/d1nr04489c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanotheranostics for fluorescence/magnetic resonance (FL/MR) dual-modal imaging guided photodynamic therapy (PDT) are highly desirable in precision and personalized medicine. In this study, a facile non-covalent electrostatic interaction induced self-assembly strategy is developed to effectively encapsulate gadolinium porphyrin (Gd-TCPP) into homogeneous supramolecular nanoparticles (referred to as Gd-PNPs). Gd-PNPs exhibit the following advantages: (1) excellent FL imaging property, high longitudinal relaxivity (16.157 mM(-1) s(-1)), and good singlet oxygen (O-1(2)) production property; (2) excellent long-term colloidal stability, dispersity and biocompatibility; and (3) enhanced in vivo FL/MR imaging guided tumor growth inhibition efficiency for CT 26 tumor-bearing mice. This study provides a new strategy to design and synthesize metalloporphyrin-based nanotheranostics for imaging-guided cancer therapy with enhanced theranostic properties.

引用

页码：16197 / 16206

页数：10

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