Common genetic variant rs3802842 in 11q23 contributes to colorectal cancer risk in Chinese population

被引：0

作者：

Zhang, Chunze ^{[1
]}

Li, Xichuan ^{[2
]}

Zhang, Weihua ^{[1
]}

Wang, Yijia ^{[3
]}

Fan, Guanwei ^{[4
,5
]}

Wang, Wenhong ^{[6
]}

Chen, Shuo ^{[1
]}

Qin, Hai ^{[1
]}

Zhang, Xipeng ^{[1
]}

机构：

[1] Tianjin Union Med Ctr, Dept Colorectal Surg, Tianjin 300121, Peoples R China

[2] Tianjin Med Univ, Dept Immunol Biochem & Mol Biol, Collaborat Innovat Ctr Tianjin Med Epigenet 2011, Tianjin Key Lab Med Epigenet, Tianjin 300070, Peoples R China

[3] Tianjin Union Med Ctr, Dept Pathol, Tianjin 300121, Peoples R China

[4] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Tianjin 300193, Peoples R China

[5] Tianjin Univ Tradit Chinese Med, State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China

[6] Tianjin Union Med Ctr, Dept Imaging, Tianjin 300121, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 42期

关键词：

colorectal cancer; rs3802842; meta-analysis; Chinese population; GENOME-WIDE ASSOCIATION; ALZHEIMERS-DISEASE SUSCEPTIBILITY; POLYMORPHISM CONTRIBUTES; RACIAL-DIFFERENCES; SAMPLES CONFIRMS; IDENTIFIES; 6; LOCI; METAANALYSIS; HIGHLIGHTS; RS9929218;

D O I：

10.18632/oncotarget.19702

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A genome-wide association study identified a common genetic variant rs3802842 at 11q23 to be associated with CRC risk with OR = 1.1 and P = 5.80E-10 in European population. In Chinese population, several genetic association studies have investigated the association between rs3802842 variant and CRC risk. However these studies reported both positive and negative association results. It is still necessary to evaluate a specific variant in a specific population, which would be informative to reveal the disease mechanism. Until recently, there is no a systemic study to evaluate the potential association between rs3802842 and CRC risk in Chinese population by a meta-analysis method. Here, we aim to evaluate this association in Chinese population by a meta-analysis method using 12077 samples including 5816 CRC cases and 6261 controls. We identified the T allele of rs3802842 to be significantly related with an increase CRC risk (P = 2.22E-05, OR = 1.14, 95% CI 1.07-1.21) in Chinese population.

引用

页码：72227 / 72234

页数：8

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