Decellularized matrices for tissue engineering

被引：236

作者：

Hoshiba, Takashi ^{[1
]}

Lu, Hongxu ^{[1
]}

Kawazoe, Naoki ^{[1
]}

Chen, Guoping ^{[1
]}

机构：

[1] Natl Inst Mat Sci, Ctr Biomat, Tsukuba, Ibaraki 3050044, Japan

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2010年 / 10卷 / 12期

关键词：

decellularization; extracellular matrix; stem cell; tissue engineering; EMBRYONIC STEM-CELLS; ANTERIOR CRUCIATE LIGAMENT; ALVEOLAR EPITHELIAL-CELLS; EXTRACELLULAR-MATRIX; BASEMENT-MEMBRANE; IN-VITRO; AMNIOTIC MEMBRANE; FUNCTIONAL-DIFFERENTIATION; ENDOTHELIAL-CELLS; SIGNALING PATHWAY;

D O I：

10.1517/14712598.2010.534079

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Importance of the field: Biomimetic scaffolds and substrates of extracellular matrices (ECMs) play an important role in the regulation of cell function and in the guidance of new tissue regeneration, as an ECM has the intrinsic cues necessary to communicate with and dictate to cells. Areas covered in this review: This paper reviews the latest developments in ECM scaffolds and substrates obtained from decellularized tissues, organs or cultured cells and their application in tissue engineering. The ECM composition, structure, interaction with surrounding cells, preparation method and usage in the regeneration of various tissues and organs are summarised. What the reader will gain: The advantages and challenges of decellularized matrices are highlighted. Take home message: Similarity in the composition, microstructure and biomechanical properties of the decellularized scaffolds and substrates to those of the native tissues and organs maximizes the promotion effect in the regeneration of both structural and functional tissues and organs. Simple tissues as well as complicated organs have been decellularized and decellularization methods have been optimized to completely remove the cellular components while keeping the ECM intact.

引用

页码：1717 / 1728

页数：12

共 98 条

[11] Chondrocyte phenotypes on different extracellular matrix monolayers [J].

Brodkin, KR ;

García, AJ ;

Levenston, ME .

BIOMATERIALS, 2004, 25 (28) :5929-5938

[12] Acellular collagen matrix as a possible "off the shelf" biomaterial for urethral repair [J].

Chen, F ;

Yoo, JJ ;

Atala, A .

UROLOGY, 1999, 54 (03) :407-410

[13] STUDIES ON INTER-CELLULAR LETS GLYCOPROTEIN MATRICES [J].

CHEN, LB ;

MURRAY, A ;

SEGAL, RA ;

BUSHNELL, A ;

WALSH, ML .

CELL, 1978, 14 (02) :377-391

[14] Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts [J].

Chen, Xiao-Dong ;

Dusevich, Vladimir ;

Feng, Jian Q. ;

Manolagas, Stavros C. ;

Jilka, Robert L. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 (12) :1943-1956

[15]

Cheng HW, 2009, TISSUE ENG PART C-ME, V15, P697, DOI 10.1089/ten.TEC.2008.0635

[16] Bioengineering endothelialized neo-corneas using donor-derived corneal endothelial cells and decellularized corneal stroma [J].

Choi, Jin San ;

Williams, James K. ;

Greven, Margaret ;

Walter, Keith A. ;

Laber, Patrick W. ;

Khang, Gilson ;

Soker, Shay .

BIOMATERIALS, 2010, 31 (26) :6738-6745

[17] The chondrogenic differentiation of mesenchymal stem cells on an extracellular matrix scaffold derived from porcine chondrocytes [J].

Choi, Kyoung-Hwan ;

Choi, Byung Hyune ;

Park, So Ra ;

Kim, Byoung Ju ;

Min, Byoung-Hyun .

BIOMATERIALS, 2010, 31 (20) :5355-5365

[18] Interactions between growth factor receptors and adhesion molecules: breaking the rules [J].

Comoglio, PM ;

Boccaccio, C ;

Trusolino, L .

CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (05) :565-571

[19] Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells [J].

D'Amour, Kevin A. ;

Bang, Anne G. ;

Eliazer, Susan ;

Kelly, Olivia G. ;

Agulnick, Alan D. ;

Smart, Nora G. ;

Moorman, Mark A. ;

Kroon, Evert ;

Carpenter, Melissa K. ;

Baetge, Emmanuel E. .

NATURE BIOTECHNOLOGY, 2006, 24 (11) :1392-1401

[20] Extracellular matrix dynamics in development and regenerative medicine [J].

Daley, William P. ;

Peters, Sarah B. ;

Larsen, Melinda .

JOURNAL OF CELL SCIENCE, 2008, 121 (03) :255-264

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