Biosynthesis of fatty acids in the docosahexaenoic acid-producing bacterium Moritella marina strain MP-I

被引：26

作者：

Morita, N ^{[1
]}

Tanaka, M

Okuyama, H

机构：

[1] MITI, AIST, Hokkaido Natl Ind Res Inst, Biosci & Chem Div,Toyohira Ku, Sapporo, Hokkaido 0628517, Japan

[2] Hokkaido Univ, Grad Sch Environm Earth Sci, Lab Environm Mol Biol, Kita Ku, Sapporo, Hokkaido 0600810, Japan

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2000年 / 28卷

关键词：

docosahexaenoic acid-biosynthetic gene cluster; fab gene cluster; fatty acid biosynthesis;

D O I：

10.1042/0300-5127:0280943

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated the fatty acid biosynthetic (fab) gene cluster taking part in the synthesis of middle-chain fatty acids and a genomic segment which was homologous with the eicosapentaenoic acid-biosynthetic gene cluster from the docosahexaenoic acid (DHA)-producing bacterium Moritella marina strain MP-1. This segment was presumed to include the DHA-biosynthetic gene cluster of M. marina strain MP-1. When M. marina strain MP-1 was cultured in medium containing cerulenin, a fatty acid synthesis inhibitor, decreases in levels of middle-chain fatty acids and remarkable increases in levels of DHA were observed. These results suggest that the synthesis of middle-chain fatty acids works independently of the synthesis of DHA.

引用

页码：943 / 945

页数：3