Biosynthesis of fatty acids in the docosahexaenoic acid-producing bacterium Moritella marina strain MP-I

被引：26
|
作者：
Morita, N [1 ]
Tanaka, M
Okuyama, H
机构：
[1] MITI, AIST, Hokkaido Natl Ind Res Inst, Biosci & Chem Div,Toyohira Ku, Sapporo, Hokkaido 0628517, Japan
[2] Hokkaido Univ, Grad Sch Environm Earth Sci, Lab Environm Mol Biol, Kita Ku, Sapporo, Hokkaido 0600810, Japan
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2000年 / 28卷
关键词：
docosahexaenoic acid-biosynthetic gene cluster; fab gene cluster; fatty acid biosynthesis;
D O I：
10.1042/0300-5127:0280943
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have isolated the fatty acid biosynthetic (fab) gene cluster taking part in the synthesis of middle-chain fatty acids and a genomic segment which was homologous with the eicosapentaenoic acid-biosynthetic gene cluster from the docosahexaenoic acid (DHA)-producing bacterium Moritella marina strain MP-1. This segment was presumed to include the DHA-biosynthetic gene cluster of M. marina strain MP-1. When M. marina strain MP-1 was cultured in medium containing cerulenin, a fatty acid synthesis inhibitor, decreases in levels of middle-chain fatty acids and remarkable increases in levels of DHA were observed. These results suggest that the synthesis of middle-chain fatty acids works independently of the synthesis of DHA.
引用
收藏
页码：943 / 945
页数：3
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