Pt(II) complexes of 4-amino-4H-1,2,4-triazole

被引：8

作者：

Kavlakova, Maia ^{[1
]}

Bakalova, Adriana ^{[1
]}

Momekov, Georgi ^{[2
]}

Ivanov, Darvin ^{[1
]}

机构：

[1] Med Univ Sofia, Dept Chem, Fac Pharm, Dhaka 1000, Bangladesh

[2] Med Univ Sofia, Dept Pharmacol Pharmacotherapy & Toxicol, Fac Pharm, Dhaka 1000, Bangladesh

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2010年 / 63卷 / 20期

关键词：

4-Amino-4H-1; 2; 4-triazole; Pt(II) complexes; Spectroscopic and structural elucidation; Cytotoxic activity; CANCER-CELL-LINES; DINUCLEAR PLATINUM(II) COMPLEXES; CRYSTAL-STRUCTURE; 1,2,4-TRIAZOLE COMPLEXES; CONTAINING PEPTIDES; ANTITUMOR-ACTIVITY; SPECTRAL-ANALYSIS; SOLID-STATE; CISPLATIN; AU(III)-COMPLEXES;

D O I：

10.1080/00958972.2010.516432

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The coordination ability of 4-amino-4H-1,2,4-triazole with Pt(II), both in solution and solid states, is elucidated by conventional and linear-polarized IR spectroscopy of oriented colloid suspensions in nematic host, 1H- and 13C-NMR, UV-Vis spectroscopy, mass spectrometry (ESI and FAB), TGV, and DSC methods. The interpretation of the spectroscopic characteristics of corresponding metal complexes is obtained by comparison with free 4-amino-4H-1,2,4-triazole. In addition, quantum chemical calculations of the last compound are performed to obtain data for electronic structures and optical properties of the ligand, thus supporting the experimental elucidation. The evaluation of the cell viability on a panel of human tumor cell lines is made. The new Pt(II) complexes exerted cytotoxic effects in a concentration-dependent manner.

引用

页码：3531 / 3540

页数：10

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