Essential considerations during vaccine design against COVID-19 and review of pioneering vaccine candidate platforms

被引：11

作者：

Bayat, Maryam ^{[1
]}

Asemani, Yahya ^{[2
]}

Najafi, Sajad ^{[3
]}

机构：

[1] Shiraz Univ Med Sci, Dept Immunol, Shiraz, Iran

[2] Shahid Beheshti Univ Med Sci, Dept Immunol, Tehran, Iran

[3] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Student Res Comm, Tehran, Iran

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2021年 / 97卷

关键词：

COVID-19; Vaccine; Design; SARS-CoV2; Adjuvant; RESPIRATORY SYNDROME CORONAVIRUS; PROTECTIVE IMMUNITY; VIRUS; IMMUNIZATION; PROTEIN; EPITOPE; MICE; SARS; RESPONSES; LESSONS;

D O I：

10.1016/j.intimp.2021.107679

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The calamity of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), COVID-19, is still a global human tragedy. To date, no specific antiviral drug or therapy has been able to break the widespread of SARS-CoV2. It has been generally believed that stimulating protective immunity via universal vaccination is the individual strategy to manage this pandemic. Achieving an effective COVID-19 vaccine requires attention to the immunological and non-immunological standpoints mentioned in this article. Here, we try to introduce the considerable immunological aspects, potential antigen targets, appropriate adjuvants as well as key points in the various stages of COVID-19 vaccine development. Also, the principal features of the preclinical and clinical studies of pioneering COVID-19 vaccine candidates were pointed out by reviewing the available information. Finally, we discuss the key challenges in the successful design of the COVID-19 vaccine and address the most fundamental strengths and weaknesses of common vaccine platforms.

引用

页数：15

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