Comparative evaluation of probiotics effects on plasma glucose, lipid, and insulin levels in streptozotocin-induced diabetic rats

被引：27

作者：

Memarrast, Faeghe ^{[1
]}

Ghafouri-Fard, Soudeh ^{[2
]}

Kolivand, Sedighe ^{[1
]}

Jafary-Nodooshan, Saeedeh ^{[1
]}

Neyazi, Nadia ^{[3
,4
]}

Sadroddiny, Esmaeil ^{[1
]}

Motevaseli, Elahe ^{[5
,6
]}

机构：

[1] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Dept Med Genet, Tehran, Iran

[3] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Int Campus, Tehran, Iran

[4] Kabul Med Univ, Dept Oncol, Kabul, Afghanistan

[5] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Mol Med, Tehran, Iran

[6] Univ Tehran Med Sci, Food Microbiol Res Ctr, Tehran, Iran

来源：

DIABETES-METABOLISM RESEARCH AND REVIEWS | 2017年 / 33卷 / 07期

关键词：

Bacillus subtilis; Lactobacillus crispatus; Lactobacillus reuteri; PPAR-gamma; type; 2; diabetes; GLUT-4; LACTOBACILLUS-CASEI; BLOOD-GLUCOSE; MELLITUS; PREVENTION; METFORMIN; MODEL;

D O I：

10.1002/dmrr.2912

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Diabetes is a chronic disorder caused by the relative decrease in insulin production from the pancreas, tissue resistance to insulin, or both. Daily consumption of probiotics, particularly Lactobacilli, has been proposed as a new strategy for prevention or control of diabetes. Methods: In the current study, the effects of various probiotics including Lactobacillus reuteri (Lreuteri), Lactobacillus crispatus (Lcrispatus), and Bacillus subtilis on the levels of blood glucose, lipid, and insulin as well as haemoglobin A(1c) (HbA(1c)) were investigated in rat models of streptozotocin (STZ)-induced diabetes and compared with metformin. In addition, GLUT-4 and PPAR-transcript levels have been analysed in adipose tissues. Results: A significant decrease in plasma glucose and HbA(1c) levels and a dramatic increase in insulin levels have been detected after consumption of probiotics. Furthermore, lipid profiles have been improved. The expression of Glut-4 and Ppar-genes in adipose tissues also increased after treatment period. Conclusion: The results of this experiment showed that daily consumption of probiotics can be effective in control of STZ-induced diabetes and its complications.

引用

页数：8

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